Institution
Adventist HealthCare
Healthcare•Gaithersburg, Maryland, United States•
About: Adventist HealthCare is a healthcare organization based out in Gaithersburg, Maryland, United States. It is known for research contribution in the topics: Angioplasty & Stent. The organization has 124 authors who have published 180 publications receiving 15203 citations. The organization is also known as: Adventist HealthCare, Inc. & Adventist HealthCare Inc.
Papers published on a yearly basis
Papers
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TL;DR: As compared with bare-metal stents, the slow-release, polymer-based, paclitaxel-eluting stent is safe and markedly reduces the rates of clinical and angiographic restenosis at nine months.
Abstract: Background Restenosis after coronary stenting necessitates repeated percutaneous or surgical revascularization procedures. The delivery of paclitaxel to the site of vascular injury may reduce the incidence of neointimal hyperplasia and restenosis. Methods At 73 U.S. centers, we enrolled 1314 patients who were receiving a stent in a single, previously untreated coronary-artery stenosis (vessel diameter, 2.5 to 3.75 mm; lesion length, 10 to 28 mm) in a prospective, randomized, double-blind study. A total of 652 patients were randomly assigned to receive a bare-metal stent, and 662 to receive an identical-appearing, slow-release, polymer-based, paclitaxel-eluting stent. Angiographic follow-up was prespecified at nine months in 732 patients. Results In terms of base-line characteristics, the two groups were well matched. Diabetes mellitus was present in 24.2 percent of patients; the mean reference-vessel diameter was 2.75 mm, and the mean lesion length was 13.4 mm. A mean of 1.08 stents (length, 21.8 mm) were...
2,617 citations
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TL;DR: The findings indicate that despite its beneficial hemodynamic actions, long-term therapy with oral milrinone increases the morbidity and mortality of patients with severe chronic heart failure.
Abstract: Background. Milrinone, a phosphodiesterase inhibitor, enhances cardiac contractility by increasing intracellular levels of cyclic AMP, but the long-term effect of this type of positive inotropic agent on the survival of patients with chronic heart failure has not been determined. Methods. We randomly assigned 1088 patients with severe chronic heart failure (New York Heart Association class III or IV) and advanced left ventricular dysfunction to double-blind treatment with 40 mg of oral milrinone daily (561 patients) or placebo (527 patients). In addition, all patients received conventional therapy with digoxin, diuretics, and a converting-enzyme inhibitor throughout the trial. The median period of follow-up was 6.1 months (range, 1 day to 20 months). Results. As compared with placebo, milrinone therapy was associated with a 28 percent increase in mortality from all causes (95 percent confidence interval, 1 to 61 percent; P = 0.038) and a 34 percent increase in cardiovascular mortality (95 percent...
2,108 citations
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TL;DR: The relative efficacy reported at 9 months for the polymer-based, paclitaxel-eluting TAXUS stent compared with the EXPRESS stent is preserved and continues to increase at 1 year, with no safety concerns apparent.
Abstract: Background— The safety and efficacy of the slow-release, polymer-based, paclitaxel-eluting stent after implantation in a broad cross section of de novo coronary lesions at 1 year are unknown. Methods and Results— In the TAXUS-IV trial, 1314 patients with single de novo coronary lesions 10 to 28 mm in length, with reference-vessel diameter 2.5 to 3.75 mm, coverable by a single study stent, were prospectively randomized to the slow-release, polymer-based, paclitaxel-eluting TAXUS stent or an identical-appearing bare-metal EXPRESS stent. By actuarial analysis, the TAXUS stent compared with the bare-metal stent reduced the 12-month rates of target-lesion revascularization by 73% (4.4% versus 15.1%, P<0.0001), target-vessel revascularization by 62% (7.1% versus 17.1%, P<0.0001), target-vessel failure by 52% (10.0% versus 19.4%, P<0.0001), and composite major adverse cardiac events by 49% (10.8% versus 20.0%, P<0.0001). The 1-year rates of cardiac death (1.4% versus 1.3%), myocardial infarction (3.5% versus 4.7...
803 citations
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TL;DR: HCMV infection of cultured SMCs enhanced p53 accumulation, which correlated temporally with IE84 expression, and HCMV, and IE84-mediated inhibition of p53 function, may contribute to the development of restenosis.
Abstract: A subset of patients who have undergone coronary angioplasty develop restenosis, a vessel renarrowing characterized by excessive proliferation of smooth muscle cells (SMCs). Of 60 human restenosis lesions examined, 23 (38 percent) were found to have accumulated high amounts of the tumor suppressor protein p53, and this correlated with the presence of human cytomegalovirus (HCMV) in the lesions. SMCs grown from the lesions expressed HCMV protein IE84 and high amounts of p53. HCMV infection of cultured SMCs enhanced p53 accumulation, which correlated temporally with IE84 expression. IE84 also bound to p53 and abolished its ability to transcriptionally activate a reporter gene. Thus, HCMV, and IE84-mediated inhibition of p53 function, may contribute to the development of restenosis.
779 citations
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TL;DR: MRI may be as accurate as CT for the detection of acute hemorrhage in patients presenting with acute focal stroke symptoms and is more accurate than CT forThe detection of chronic intracerebral hemorrhage.
Abstract: ContextNoncontrast computed tomography (CT) is the standard brain imaging study
for the initial evaluation of patients with acute stroke symptoms. Multimodal
magnetic resonance imaging (MRI) has been proposed as an alternative to CT
in the emergency stroke setting. However, the accuracy of MRI relative to
CT for the detection of hyperacute intracerebral hemorrhage has not been demonstrated.ObjectiveTo compare the accuracy of MRI and CT for detection of acute intracerebral
hemorrhage in patients presenting with acute focal stroke symptoms.Design, Setting, and PatientsA prospective, multicenter study was performed at 2 stroke centers (UCLA
Medical Center and Suburban Hospital, Bethesda, Md), between October 2000
and February 2003. Patients presenting with focal stroke symptoms within 6
hours of onset underwent brain MRI followed by noncontrast CT.Main Outcome MeasuresAcute intracerebral hemorrhage and any intracerebral hemorrhage diagnosed
on gradient recalled echo (GRE) MRI and CT scans by a consensus of 4 blinded
readers.ResultsThe study was stopped early, after 200 patients were enrolled, when
it became apparent at the time of an unplanned interim analysis that MRI was
detecting cases of hemorrhagic transformation not detected by CT. For the
diagnosis of any hemorrhage, MRI was positive in 71 patients with CT positive
in 29 (P<.001). For the diagnosis of acute hemorrhage,
MRI and CT were equivalent (96% concordance). Acute hemorrhage was diagnosed
in 25 patients on both MRI and CT. In 4 other patients, acute hemorrhage was
present on MRI but not on the corresponding CT—each of these 4 cases
was interpreted as hemorrhagic transformation of an ischemic infarct. In 3
patients, regions interpreted as acute hemorrhage on CT were interpreted as
chronic hemorrhage on MRI. In 1 patient, subarachnoid hemorrhage was diagnosed
on CT but not on MRI. In 49 patients, chronic hemorrhage, most often microbleeds,
was visualized on MRI but not on CT.ConclusionMRI may be as accurate as CT for the detection of acute hemorrhage in
patients presenting with acute focal stroke symptoms and is more accurate
than CT for the detection of chronic intracerebral hemorrhage.
683 citations
Authors
Showing all 124 results
Name | H-index | Papers | Citations |
---|---|---|---|
William C. Roberts | 122 | 1117 | 55285 |
Michael J. Domanski | 60 | 164 | 26359 |
Mark Turco | 48 | 104 | 12538 |
Niv Ad | 36 | 185 | 7499 |
Jeffrey M. Isner | 31 | 73 | 4300 |
Fayaz A. Shawl | 19 | 44 | 3056 |
Robert B. Gherman | 18 | 37 | 1664 |
Paul H. Tanser | 16 | 31 | 3045 |
Samuel B. Itscoitz | 15 | 21 | 1890 |
Paul S. Massimiano | 14 | 21 | 449 |
Robert DiBianco | 14 | 23 | 3371 |
C.K. Chung | 13 | 20 | 752 |
Renu Virmani | 10 | 32 | 553 |
R DiBianco | 9 | 12 | 559 |
Marc Wish | 7 | 9 | 419 |