Hamamatsu University

About: Hamamatsu University is a education organization based out in Hamamatsu, Japan. It is known for research contribution in the topics: Cancer & Population. The organization has 733 authors who have published 650 publications receiving 12018 citations. The organization is also known as: Hamamatsu Daigaku.

Abnormal Excretion of Urinary Steroids in Endometrial Cancer

Abstract: Steroid metabolism in three premenopausal and 28 postmenopausa l patients with endometrial cancer was investigated by determining the excretion of 14 neutral steroids in 24-hr urine specimens. When compared with 55 postmenopausal normal controls, the postmenopausal patients had depressed excretion of I 1-deoxy-17-ketosteroids and increased excretion of 1 1-ketoandrosterone. The excretion of urinary pregnanes and corticosteroids was also depressed in the patient group as compared with the control group. The deviations in urinary steroids of cancer patients were not affected by radical surgery. Evidences indicated that the steroidal abnormalities in endometrial cancer patients, as distinguished from those in patients with cancer of the breast or uterine cervix, are related to a homeostatic impairment in the metabolism of testosterone and progesterone. Epidemiological analysis showed that patients with endometrial cancer were distinguishable from the urban controls by decreased height and relative infertility, and from the rural controls by increased weight, acceleration of menarche, and relative infertility, a finding which suggests a long-lasting depression of endogenous testosterone and progesterone.

Preoperative CT Findings for Predicting Acute Exacerbation of Interstitial Pneumonia After Lung Cancer Surgery: A Multicenter Case-Control Study

Abstract: Please see the Editorial Comment by Brian M. Haas discussing this article. BACKGROUND. Acute exacerbation (AE) is a life-threatening complication of inter-stitial pneumonia (IP). Thoracic surgery m...

Validation of the STRATIFY Falls Risk Assessment Tool in a Japanese Acute Care Hospital Setting

Abstract: Patient falls are the most frequent adverse events that occur in a hospital. Prevention of inpatient falls is performed by a strategy to target patients at high risk for falls determined by a falls risk assessment system such as the STRATIFY tool. However, the performance of the STRATIFY tool in a Japanese hospital setting has not been determined. We tried to verify the performance of the STRATIFY tool for predicting falls in acutely hospitalized patients in Japan by a multi-center study. A total of 113,413 patients admitted to four acute cares national university hospitals during the period from April 2010 to March 2012 were studied. Inpatient falls per 1,000 patient-days varied from 1.42 to 2.92 in the four hospitals. The STRATIFY score was calculated on the basis of data extracted electronically from the hospital information system. Although the distribution of STRATIFY scores differed significantly among the four hospitals, logistic regression analysis and survival analysis showed that the proportion of high-risk patients who fell was significantly larger than the proportion of low-risk patients in all of the four hospitals. The odds ratio and hazard ratio for high-risk patients versus low-risk patients were 2.5 to 4.3 (combined estimate, 3.9 (95% confidence interval (95% CI), 2.1 to 7.6) and 1.8 to 5.1 (combined estimate, 3.1 (95% CI, 2.1 to 4.6)), respectively. The results suggest that the STRATIFY tool can be used as a screening tool to detect patients at high risk for falls in a Japanese acute care setting as used commonly in other countries.

Ease of Taking and Palatability of Fixed-Dose Orally Disintegrating Mitiglinide/Voglibose Tablets.

Abstract: Fixed-dose combination (FDC) medicines containing two or more active pharmaceutical ingredients (APIs) in a single dosage form have been reported to improve patient adherence to a greater extent than single dosages of individual components (ICs). Orally disintegrating tablets (ODTs) are easier to swallow than conventional tablets. The aim of this study was to elucidate the clinical pharmaceutical characteristics of taking a FDC-ODT and two IC-ODTs. We prepared three ODTs containing mitiglinide, voglibose, and mitiglinide/voglibose and three corresponding placebo ODTs and performed 2 independent clinical trials with 13 healthy subjects (mean age, 23.4 ± 1.6 years). One trial evaluated the ease of taking tablets and the amount of water required for taking the tablets; placebo ODTs were used in order to avoid administering APIs. The other trial evaluated the bitterness, sweetness and overall palatability of ODTs containing APIs during disintegration and after spitting out. Ease and taste were evaluated using both a visual analog scale (VAS) and a verbal rating scale (VRS). The results of the VAS and VRS evaluation indicated that FDC-ODT could ease tablet intake unlike IC-ODTs. In addition, FDC-ODT reduced the amount of water required for tablet intake in contrast to IC-ODTs. Taste evaluation results did not reveal any difference between FDC-ODT and IC-ODTs, except for the sweetness score after spitting out. In conclusion, FDC-ODT is easy to take and can help improve patient adherence.