Institution
Mercy Hospital for Women
Healthcare•Melbourne, Victoria, Australia•
About: Mercy Hospital for Women is a healthcare organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Pregnancy & Population. The organization has 682 authors who have published 1257 publications receiving 34582 citations.
Topics: Pregnancy, Population, Placenta, Preeclampsia, Gestational diabetes
Papers published on a yearly basis
Papers
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TL;DR: It is proposed that spontaneous onset labour and delivery are consequent upon withdrawal of the repressive effect of nuclear receptors (PPAR and PR) on pro-labour TF pathways (NF-kappaB) and coordination of these different pathways is achieved by competition for common cofactors that control the activity of NRs in human gestational tissues.
61 citations
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TL;DR: In this article, a prospective observational study of all women admitted to a single center in Tanzania between May 1, 2007 and April 30, 2008 who had an eclamptic seizure was conducted.
61 citations
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University of Lausanne1, National Institute for Health Research2, University of Paris3, University of Barcelona4, Mario Negri Institute for Pharmacological Research5, Mercy Hospital for Women6, Newcastle upon Tyne Hospitals NHS Foundation Trust7, Newcastle University8, Centre national de la recherche scientifique9, Cochin University of Science and Technology10, Complutense University of Madrid11, University College Hospital12, Ohio State University13
TL;DR: An international multidisciplinary working group summarizes the current knowledge of these potentially severe disorders and proposes a practical clinical approach to diagnose and manage an episode of pregnancy-associated TMA.
61 citations
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TL;DR: Using aspirin during pregnancy is associated with increased post partum bleeding and postpartum hematoma and it may also be associated with neonatal intracranial hemorrhage.
61 citations
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TL;DR: The aims of this study were to determine the effects of the TLR5 ligand flagellin and theTLR2 ligand FSL‐1 on pro‐inflammatory and pro‐labour mediators in human fetal membranes and myometrium, and to establish whether their actions are dependent on MyD88, TRAF6 and NF‐κB.
Abstract: Problem
Toll-like receptors (TLRs) 2 and 5 induce inflammation via the adapter proteins myeloid differentiation factor 88 (MyD88) and TNFR-associated factor 6 (TRAF6) and the transcription factor nuclear factor-kappa B (NF-κB). The aims of this study were to determine the effects of the TLR5 ligand flagellin and the TLR2 ligand FSL-1 on pro-inflammatory and pro-labour mediators in human fetal membranes and myometrium, and to establish whether their actions are dependent on MyD88, TRAF6 and NF-κB.
Method of Study
Tissue explants were performed to determine the effect of flagellin and FSL-1 on pro-labour mediators in fetal membranes and myometrium. siRNA knockdown was performed in primary amnion and myometrium cells to determine the role of MyD88, TRAF6 and NF-κB.
Results
Flagellin and FSL-1 increased pro-inflammatory cytokines (IL-6 and IL-8), MMP-9 expression and activity, and COX-2 expression and prostaglandin release. siRNA knockdown of TLR2 decreased FSL-1 induced production of IL-6, IL-8, COX-2, prostaglandins and MMP-9; similarly, siRNA knockdown of TLR5 decreased flagellin induced production of these pro-labour mediators. The effects of flagellin and FSL-1 are mediated by MyD88 and TRAF6, as siRNA knockdown of MyD88 and TRAF6 decreased flagellin and FSL-1 induced pro-labour mediators. Additionally, the effects of flagellin and FSL-1 are mediated via NF-κB, as flagellin and FSL-1 increased NF-κB transcriptional activity, and the NF-κB inhibitor BAY 11-7082 attenuated flagellin and FSL-1 induced expression and secretion of pro-labour mediators.
Conclusion
TLR2 engagement by the synthetic lipoprotein FSL-1 and TLR5 engagement by bacterial flagellin enhances pro-inflammatory and pro-labour mediators in human fetal membranes and myometrium via MyD88/TRAF6/NF-κB.
61 citations
Authors
Showing all 687 results
Name | H-index | Papers | Citations |
---|---|---|---|
Christopher G. Maher | 128 | 940 | 73131 |
David J. Hill | 107 | 1364 | 57746 |
Lex W. Doyle | 99 | 625 | 38138 |
David K. Gardner | 92 | 398 | 25301 |
Michael A. Quinn | 80 | 399 | 24052 |
Suzanne M. Garland | 76 | 700 | 31857 |
Peter Rogers | 67 | 408 | 14442 |
Gini F. Fleming | 66 | 323 | 19686 |
Danny Rischin | 61 | 335 | 17767 |
Sepehr N. Tabrizi | 56 | 346 | 12003 |
Gregory E. Rice | 55 | 311 | 10832 |
Elizabeth A. Thomas | 50 | 172 | 7740 |
David J. Amor | 49 | 246 | 9165 |
Michael Permezel | 47 | 159 | 6451 |
Shaun P. Brennecke | 47 | 310 | 8783 |