Institution
National University of Ireland, Galway
Education•Galway, Ireland•
About: National University of Ireland, Galway is a education organization based out in Galway, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 10507 authors who have published 24227 publications receiving 707219 citations.
Topics: Population, Context (language use), Health care, Irish, Medicine
Papers published on a yearly basis
Papers
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TL;DR: In this article, the principles governing the application of the conceptual model technique to river flow forecasting are discussed and the necessity for a systematic approach to the development and testing of the model is explained and some preliminary ideas suggested.
19,601 citations
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
11,809 citations
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
7,021 citations
TL;DR: The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
6,861 citations
TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Abstract: Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
6,809 citations
Authors
Showing all 10657 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Patrick W. Serruys | 186 | 2427 | 173210 |
| Tien Yin Wong | 160 | 1880 | 131830 |
| Pete Smith | 156 | 2464 | 138819 |
| Rui Zhang | 151 | 2625 | 107917 |
| Debbie A Lawlor | 147 | 1114 | 101123 |
| Robert J. Glynn | 146 | 748 | 88387 |
| William Wijns | 127 | 752 | 95517 |
| John F. Cryan | 124 | 723 | 58938 |
| Ian Tomlinson | 119 | 607 | 55576 |
| Fergus Shanahan | 117 | 705 | 51963 |
| Mike Clarke | 113 | 1037 | 164328 |
| Wim E. Hennink | 110 | 600 | 49940 |
| Francis J. Giles | 105 | 673 | 39961 |
| Elisabeth Kremmer | 99 | 413 | 34720 |
| Andrew M. McIntosh | 98 | 693 | 50664 |