F
Fergus Shanahan
Researcher at National University of Ireland
Publications - 727
Citations - 59181
Fergus Shanahan is an academic researcher from National University of Ireland. The author has contributed to research in topics: Inflammatory bowel disease & Gut flora. The author has an hindex of 117, co-authored 705 publications receiving 51963 citations. Previous affiliations of Fergus Shanahan include Imperial College London & Mater Misericordiae Hospital.
Papers
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Journal ArticleDOI
Gut microbiota composition correlates with diet and health in the elderly
Marcus J. Claesson,Ian B. Jeffery,Susana Conde,Susan E. Power,Eibhlís M. O'Connor,Siobhán Cusack,Hugh M. B. Harris,M. Coakley,Bhuvaneswari Lakshminarayanan,Orla O'Sullivan,Gerald F. Fitzgerald,Jennifer Deane,Michael O'Connor,Norma Harnedy,Kieran O'Connor,Denis O'Mahony,Denis O'Mahony,Douwe van Sinderen,Martina Wallace,Lorraine Brennan,Catherine Stanton,Catherine Stanton,Julian R. Marchesi,Anthony P. Fitzgerald,Fergus Shanahan,Colin Hill,R. Paul Ross,R. Paul Ross,Paul W. O'Toole +28 more
TL;DR: The data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.
Journal ArticleDOI
The gut flora as a forgotten organ
Ann M O'Hara,Fergus Shanahan +1 more
TL;DR: The flora has a collective metabolic activity equal to a virtual organ within an organ, and the mechanisms underlying the conditioning influence of the bacteria on mucosal homeostasis and immune responses are beginning to be unravelled.
Journal ArticleDOI
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
Marcus J. Claesson,Siobhán Cusack,Orla O'Sullivan,Rachel Greene-Diniz,Heleen de Weerd,E. Flannery,Julian R. Marchesi,Julian R. Marchesi,Daniel Falush,Timothy G. Dinan,Gerald F. Fitzgerald,Catherine Stanton,Catherine Stanton,Douwe van Sinderen,Michael O'Connor,Norma Harnedy,Kieran O'Connor,Colm Henry,Denis O'Mahony,Denis O'Mahony,Anthony P. Fitzgerald,Fergus Shanahan,C. Twomey,C. Twomey,Colin Hill,R. Paul Ross,R. Paul Ross,Paul W. O'Toole +27 more
TL;DR: It is concluded that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability.
Journal ArticleDOI
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
Liam O'Mahony,Jane McCarthy,Peter Kelly,George J Hurley,Fangyi Luo,Ker-Sang Chen,Gerald C. O'Sullivan,Barry Kiely,J. Kevin Collins,Fergus Shanahan,Eamonn Martin Quigley +10 more
TL;DR: B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.
Journal ArticleDOI
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Gerard Clarke,Sue Grenham,Paul Scully,Patrick Fitzgerald,Rachel D. Moloney,Fergus Shanahan,Timothy G. Dinan,John F. Cryan +7 more
TL;DR: It is demonstrated that CNS neurotransmission can be profoundly disturbed by the absence of anormal gut microbiota and that this aberrant neurochemical, but not behavioural, profile is resistant to restoration of a normal gut flora in later life.