Semnan University

About: Semnan University is a education organization based out in Semnan, Semnān, Iran. It is known for research contribution in the topics: Heat transfer & Nanofluid. The organization has 5531 authors who have published 9778 publications receiving 119986 citations.

Importance of probiotics in the prevention and treatment of colorectal cancer.

Abstract: Colorectal cancer (CRC) remains one of the most common and deadly cancers. Intestinal gut microflora is important to maintain and contributes to several intestinal functions, including the development of the mucosal immune system, absorption of complex macromolecules, synthesis of amino acids/vitamins and the protection against pathogenic microorganisms. It is well known that the gut microbiota changes or dysbiosis may have an essential impact in the initiation and promotion of chronic inflammatory pathways and also have a profound different genetic and epigenetic alterations leading to dysplasia, clonal expansion, and malignant transformation. Probiotic bacteria has antitumor activity with various mechanisms such as nonspecific physiological and immunological mechanisms. This review evaluates the effects of microbiota and probiotics in clinical trials, in vitro and animal model studies that have explored how probiotic against cancer development and also discusses the possible immunomodulatory mechanisms. Several mechanisms alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host's immune response; antiproliferative effects via regulation of apoptosis and cell differentiation; fermentation of undigested food; inhibition of tyrosine kinase; reduces the enteropathogenic complications before and after colon cancer surgery and improve diarrhea and it's have been able to create the integrity of gut mucosal and have stimulatory effects on the systemic immune system and prevent the CRC metastasis. Research in clinical trials encouraging findings that support a role of probiotics in CRC prevention and improve the safety and effectiveness of cancer therapy even though additional clinical research is still necessary.

Day-ahead electricity price forecasting by modified relief algorithm and hybrid neural network

Abstract: In a power market, the price of electricity is the most important signal to all market participants. However, electricity price forecast is a complex task due to non-linearity, non-stationarity and volatility of the price signal. In spite of all performed research on this area in the recent years, there is still an essential need for more accurate price forecast methods. Besides, there is a lack of robust feature selection technique for designing the input vector of electricity price forecast, which can consider the non-linearities of the price signal. In this study, a new price forecast method is proposed, which is composed of a modified version of Relief algorithm for feature selection and a hybrid neural network for prediction. The proposed approach is examined on Ontario, New England and Italian electricity markets and compared with some of the most recently published price forecast methods.

Influence of parameters on the photocatalytic degradation of tetracycline in wastewater: A review

Abstract: Water pollution by organic pollutants is an ever-increasing problem for the global concerns. Some recently published papers are reviewed and summarized with the focus being on the photocatalytic oxidation of tetracycline in wastewater effluent. In this review, the effects of various operating parameters on the photocatalytic degradation of tetracycline are presented. Recent findings suggested that type of photocatalyst and composition, initial substrate concentration, amount of catalyst, pH of the reaction medium, ionic components in water, solvent types, and oxidizing agents/electron acceptors can play an important role on the photocatalytic degradation of tetracycline.

Cancer stem cells: A review from origin to therapeutic implications.

Abstract: Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are elucidated as cells that can perpetuate themselves via autorestoration. These cells are highly resistant to current therapeutic approaches and are the main reason for cancer recurrence. Radiotherapy has made a lot of contributions to cancer treatment. However, despite continuous achievements, therapy resistance and tumor recurrence are still prevalent in most patients. This resistance might be partly related to the existence of CSCs. In the present study, recent advances in the investigation of different biological properties of CSCs, such as their origin, markers, characteristics, and targeting have been reviewed. We have also focused our discussion on radioresistance and adaptive responses of CSCs and their related extrinsic and intrinsic influential factors. In summary, we suggest CSCs as the prime therapeutic target for cancer treatment.