Institution
University of Molise
Education•Campobasso, Italy•
About: University of Molise is a education organization based out in Campobasso, Italy. It is known for research contribution in the topics: Population & Psoriatic arthritis. The organization has 1482 authors who have published 5167 publications receiving 122011 citations. The organization is also known as: Università degli Studi del Molise & Universita degli Studi del Molise.
Papers published on a yearly basis
Papers
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TL;DR: Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions.
Abstract: Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages. At the same time, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer), including sarcopenia and frailty. Different types of oxidative stress biomarkers have been identified and may provide important information about the efficacy of the treatment, guiding the selection of the most effective drugs/dose regimens for patients and, if particularly relevant from a pathophysiological point of view, acting on a specific therapeutic target. Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions. The purpose of this paper is to provide a review of literature on this complex topic of ever increasing interest.
2,101 citations
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University of Vienna1, Austrian Academy of Sciences2, Ilia State University3, Slovak Academy of Sciences4, University of Innsbruck5, University of Granada6, Mediterranean Agronomic Institute of Chania7, Norwegian University of Science and Technology8, Russian Academy of Sciences9, University of Molise10, Babeș-Bolyai University11, University of Pavia12, University of Geneva13, University of Parma14, University of Lausanne15, Open University of Cyprus16
TL;DR: In this article, the authors used 867 vegetation samples above the treeline from 60 summit sites in all major European mountain systems to show that ongoing climate change gradually transforms mountain plant communities.
Abstract: Climate impact studies have indicated ecological fingerprints of recent global warming across a wide range of habitats1, 2. Although these studies have shown responses from various local case studies, a coherent large-scale account on temperature-driven changes of biotic communities has been lacking3, 4. Here we use 867 vegetation samples above the treeline from 60 summit sites in all major European mountain systems to show that ongoing climate change gradually transforms mountain plant communities. We provide evidence that the more cold-adapted species decline and the more warm-adapted species increase, a process described here as thermophilization. At the scale of individual mountains this general trend may not be apparent, but at the larger, continental scale we observed a significantly higher abundance of thermophilic species in 2008, compared with 2001. Thermophilization of mountain plant communities mirrors the degree of recent warming and is more pronounced in areas where the temperature increase has been higher. In view of the projected climate change5, 6 the observed transformation suggests a progressive decline of cold mountain habitats and their biota.
943 citations
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TL;DR: The literature about the major volatile and non-volatile phytoconstituents of onion and garlic has been reviewed, with particular attention given to the different methodology developed to perform chemical analysis, including separation and structural elucidation.
786 citations
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University of Leeds1, University of California, San Diego2, University of Washington3, Hospital Italiano de Buenos Aires4, University of Southern California5, Geneva College6, Toronto Western Hospital7, University of Cagliari8, LSU Health Sciences Center New Orleans9, University College Dublin10, University of Toronto11, Tufts Medical Center12, Cleveland Clinic13, University of Iceland14, University of Molise15, Royal National Hospital for Rheumatic Diseases16, University of Queensland17, University of Pennsylvania18, Johns Hopkins University School of Medicine19, Chapel Allerton Hospital20, Hospital for Special Surgery21, University of California, Davis22, University of Rochester Medical Center23
TL;DR: To update the 2009 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for the spectrum of manifestations affecting patients with psoriatic arthritis (PsA).
Abstract: Objective
To update the 2009 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for the spectrum of manifestations affecting patients with psoriatic arthritis (PsA).
Methods
GRAPPA rheumatologists, dermatologists, and PsA patients drafted overarching principles for the management of PsA, based on consensus achieved at face-to-face meetings and via online surveys. We conducted literature reviews regarding treatment for the key domains of PsA (arthritis, spondylitis, enthesitis, dactylitis, skin disease, and nail disease) and convened a new group to identify pertinent comorbidities and their effect on treatment. Finally, we drafted treatment recommendations for each of the clinical manifestations and assessed the level of agreement for the overarching principles and treatment recommendations among GRAPPA members, using an online questionnaire.
Results
Six overarching principles had ≥80% agreement among both health care professionals (n = 135) and patient research partners (n = 10). We developed treatment recommendations and a schema incorporating these principles for arthritis, spondylitis, enthesitis, dactylitis, skin disease, nail disease, and comorbidities in the setting of PsA, using the Grading of Recommendations, Assessment, Development and Evaluation process. Agreement of >80% was reached for approval of the individual recommendations and the overall schema.
Conclusion
We present overarching principles and updated treatment recommendations for the key manifestations of PsA, including related comorbidities, based on a literature review and consensus of GRAPPA members (rheumatologists, dermatologists, other health care providers, and patient research partners). Further updates are anticipated as the therapeutic landscape in PsA evolves.
717 citations
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Austrian Academy of Sciences1, University of Vienna2, Ilia State University3, Spanish National Research Council4, University of Innsbruck5, University of Granada6, Mediterranean Agronomic Institute of Chania7, Norwegian University of Science and Technology8, Slovak Academy of Sciences9, Russian Academy of Sciences10, University of Molise11, Babeș-Bolyai University12, University of Pavia13, University of Geneva14, University of Parma15, University of Lausanne16
TL;DR: Recent changes in vascular plant species richness observed in a standardized monitoring network across Europe’s major mountain ranges are presented and indicate that high-altitude species, and in particular the rich endemic alpine flora of many Mediterranean mountain ranges, will come under increasing pressure in the predicted warmer and drier climates in this region.
Abstract: In mountainous regions, climate warming is expected to shift species' ranges to higher altitudes. Evidence for such shifts is still mostly from revisitations of historical sites. We present recent (2001 to 2008) changes in vascular plant species richness observed in a standardized monitoring network across Europe's major mountain ranges. Species have moved upslope on average. However, these shifts had opposite effects on the summit floras' species richness in boreal-temperate mountain regions (+3.9 species on average) and Mediterranean mountain regions (-1.4 species), probably because recent climatic trends have decreased the availability of water in the European south. Because Mediterranean mountains are particularly rich in endemic species, a continuation of these trends might shrink the European mountain flora, despite an average increase in summit species richness across the region.
669 citations
Authors
Showing all 1525 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stéphane Viel | 93 | 442 | 42317 |
Victor J. Hruby | 88 | 1126 | 42159 |
Luigi Terracciano | 85 | 555 | 28574 |
Angelo A. Izzo | 80 | 253 | 19856 |
Antonio C. Bianco | 71 | 251 | 19480 |
Gabriella Ferrandina | 64 | 475 | 15883 |
Enio Martino | 62 | 343 | 13545 |
Rocco Oliveto | 58 | 202 | 10522 |
Charles Dumontet | 57 | 239 | 12402 |
Maurizio Taglialatela | 56 | 204 | 8743 |
Ignazio Olivieri | 55 | 246 | 11885 |
Marco Sarchiapone | 53 | 167 | 10099 |
Nicola Ferrara | 52 | 306 | 8734 |
Raffaele Capasso | 51 | 201 | 8508 |
Sandra Torriani | 51 | 178 | 7680 |