University of Twente

About: University of Twente is a education organization based out in Enschede, Overijssel, Netherlands. It is known for research contribution in the topics: Context (language use) & Population. The organization has 15890 authors who have published 39988 publications receiving 1173424 citations. The organization is also known as: Universiteit Twente.

Extrusion Bioprinting of Shear-Thinning Gelatin Methacryloyl Bioinks

Abstract: Bioprinting is an emerging technique for the fabrication of 3D cell-laden constructs. However, the progress for generating a 3D complex physiological microenvironment has been hampered by a lack of advanced cell-responsive bioinks that enable bioprinting with high structural fidelity, particularly in the case of extrusion-based bioprinting. Herein, this paper reports a novel strategy to directly bioprint cell-laden gelatin methacryloyl (GelMA) constructs using bioinks of GelMA physical gels (GPGs) achieved through a simple cooling process. Attributed to their shear-thinning and self-healing properties, the GPG bioinks can retain the shape and form integral structures after deposition, allowing for subsequent UV crosslinking for permanent stabilization. This paper shows the structural fidelity by bioprinting various 3D structures that are typically challenging to fabricate using conventional bioinks under extrusion modes. Moreover, the use of the GPG bioinks enables direct bioprinting of highly porous and soft constructs at relatively low concentrations (down to 3%) of GelMA. It is also demonstrated that the bioprinted constructs not only permit cell survival but also enhance cell proliferation as well as spreading at lower concentrations of the GPG bioinks. It is believed that such a strategy of bioprinting will provide many opportunities in convenient fabrication of 3D cell-laden constructs for applications in tissue engineering, regenerative medicine, and pharmaceutical screening.

MCMC estimation and some model-fit analysis of multidimensional IRT models

Abstract: A Bayesian procedure to estimate the three-parameter normal ogive model and a generalization of the procedure to a model with multidimensional ability parameters are presented. The procedure is a generalization of a procedure by Albert (1992) for estimating the two-parameter normal ogive model. The procedure supports analyzing data from multiple populations and incomplete designs. It is shown that restrictions can be imposed on the factor matrix for testing specific hypotheses about the ability structure. The technique is illustrated using simulated and real data.

Interface Ferromagnetism and Orbital Reconstruction in BiFeO3-La0.7Sr0.3MnO3 Heterostructures

Abstract: We report the formation of a novel ferromagnetic state in the antiferromagnet BiFeO3 at the interface with ferromagnet La0.7Sr0.3MnO3. Using x-ray magnetic circular dichroism at Mn and Fe L2,3 edges, we discovered that the development of this ferromagnetic spin structure is strongly associated with the onset of a significant exchange bias. Our results demonstrate that the magnetic state is directly related to an electronic orbital reconstruction at the interface, which is supported by the linearly polarized x-ray absorption measurement at the oxygen K edge

Prototyping to Reach Product Quality

Abstract: This chapter provides a framework for product quality consisting of the following three criteria: validity, practicality and effectiveness, and provides insight into the applicability of the framework in various domains of educational product development.