West Virginia University

About: West Virginia University is a education organization based out in Morgantown, West Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 25632 authors who have published 48308 publications receiving 1343934 citations. The organization is also known as: WVU & West Virginia University, WVU.

Internet of Things and Big Data Analytics for Smart and Connected Communities

Abstract: This paper promotes the concept of smart and connected communities SCC, which is evolving from the concept of smart cities. SCC are envisioned to address synergistically the needs of remembering the past (preservation and revitalization), the needs of living in the present (livability), and the needs of planning for the future (attainability). Therefore, the vision of SCC is to improve livability, preservation, revitalization, and attainability of a community. The goal of building SCC for a community is to live in the present, plan for the future, and remember the past. We argue that Internet of Things (IoT) has the potential to provide a ubiquitous network of connected devices and smart sensors for SCC, and big data analytics has the potential to enable the move from IoT to real-time control desired for SCC. We highlight mobile crowdsensing and cyber-physical cloud computing as two most important IoT technologies in promoting SCC. As a case study, we present TreSight, which integrates IoT and big data analytics for smart tourism and sustainable cultural heritage in the city of Trento, Italy.

Patient-related barriers to management of cancer pain

Abstract: Patients' reluctance to report pain and to use analgesics are considered major barriers to pain management. To explore this problem, 270 patients with cancer completed a 27-item self-report questionnaire (BQ) that assessed the extent to which they have concerns about reporting pain and using pain medication. The 8 specific concerns included fear of addiction, beliefs that 'good' patients do not complain about pain, and concern about side effects. Patients also completed a measure of pain severity and pain interference (the BPI). The percentages of patients having concerns assessed by the BQ ranged from 37% to 85%. Those who were older, less educated, or had lower incomes were more likely to have concerns. Higher levels of concern were correlated with higher levels of pain. Based on their reports of pain medications used in the past week and on their reports of pain severity, patients were categorized as under-medicated versus adequately medicated. Those who were under-medicated reported significantly higher levels of concern. The data are discussed in terms of implications for research and practice.

Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.

Abstract: Tonic basal release of nitric oxide (NO) by vascular endothelial cells controls blood pressure (BP) in the basal state. In these studies we investigated the effects of chronic inhibition of basal NO synthesis in the rat for a 2-mo period. Significant systemic hypertension developed in chronically NO-blocked rats compared to controls. Marked renal vasoconstriction was also observed with elevations in glomerular blood pressure (PGC) and reductions in the glomerular capillary ultrafiltration coefficient (Kf). Chronically NO-blocked rats also develop proteinuria and glomerular sclerotic injury compared to controls. These studies therefore describe a new model of systemic hypertension with glomerular capillary hypertension and renal disease due to chronic blockade of endogenous NO synthesis. These observations highlight the importance of the endogenous NO system in control of normal vascular tone and suggest that hypertensive states may result from relative NO deficiency.

Long-term consequences of childhood physical abuse

Abstract: This article reviews the literature on the long-term consequences of childhood physical abuse. Empirical research is discussed within 7 topic areas: aggressive and violent behavior, nonviolent criminal behavior, substance abuse, self-injurious and suicidal behavior, emotional problems, interpersonal problems, and academic and vocational difficulties. The studies reviewed involve primarily adult populations, although pertinent findings from literature on children and adolescents are briefly summarized. Some variables that affect the relation between physical abuse and long-term consequences are examined. These moderator variables include maltreatment characteristics, individual factors, family factors, and environmental factors. The article ends with suggestions for future research on long-term consequences and variables that may affect these outcomes.

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

Abstract: We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.