Institution
West Virginia University
Education•Morgantown, West Virginia, United States•
About: West Virginia University is a education organization based out in Morgantown, West Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 25632 authors who have published 48308 publications receiving 1343934 citations. The organization is also known as: WVU & West Virginia University, WVU.
Topics: Population, Poison control, Medicine, Pulsar, Health care
Papers published on a yearly basis
Papers
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TL;DR: Investigation of the pulmonary toxicity of multi-walled carbon nanotubes in mice indicated that MWCNT exposure rapidly produces significant adverse health outcomes in the lung, and the observation that M WCNT reach the pleura after aspiration exposure indicates that more extensive investigations are needed to fully assess if pleural penetration results in any adverse health outcome.
469 citations
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TL;DR: In this article, the population of 47 compact binary mergers detected with a false-alarm rate of 0.614 were dynamically assembled, and the authors found that the BBH rate likely increases with redshift, but not faster than the star formation rate.
Abstract: We report on the population of 47 compact binary mergers detected with a false-alarm rate of 0.01 are dynamically assembled. Third, we estimate merger rates, finding RBBH = 23.9-+8.614.3 Gpc-3 yr-1 for BBHs and RBNS = 320-+240490 Gpc-3 yr-1 for binary neutron stars. We find that the BBH rate likely increases with redshift (85% credibility) but not faster than the star formation rate (86% credibility). Additionally, we examine recent exceptional events in the context of our population models, finding that the asymmetric masses of GW190412 and the high component masses of GW190521 are consistent with our models, but the low secondary mass of GW190814 makes it an outlier.
468 citations
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TL;DR: The authors investigated the dimensionality and measurement of self-reported self-disclosure and found that self-perceptions of disclosure to 20 "target" persons were found to involve at least five relatively uncorrelated dimensions.
Abstract: This study investigated the dimensionality and measurement of self-reported self-disclosure. Self-perceptions of disclosure to 20 “target” persons were found to involve at least five relatively uncorrelated dimensions. An initial instrument was developed for measuring these dimensions. Further improvement in measurement was recommended.
467 citations
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TL;DR: This study suggests a new mechanism of higher ROS production in ovarian cancer cells and provides strong evidence that endogenous ROS play an important role for cancer cells to induce angiogenesis and tumor growth.
Abstract: Reactive oxygen species (ROS) are associated with multiple cellular functions such as cell proliferation, differentiation, and apoptosis. However, the direct roles of endogenous ROS production still remain to be elucidated. In this study, we found that high levels of ROS were spontaneously produced by ovarian and prostate cancer cells. This elevated ROS production was inhibited by NADPH oxidase inhibitor diphenylene iodonium (DPI) and mitochondria electron chain inhibitor rotenone in the cells. To further analyze the source of ROS production, we found that ovarian cancer cells have much higher expression of NOX4 NADPH oxidase, and that specific inhibition of NADPH oxidase subunit p47(phox) diminished ROS production. To analyze the functional relevance of ROS production, we showed that ROS regulated hypoxia-inducible factor 1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in ovarian cancer cells. Elevated levels of endogenous ROS were required for inducing angiogenesis and tumor growth. NOX4 knockdown in ovarian cancer cells decreased the levels of VEGF and HIF-1 alpha and tumor angiogenesis. This study suggests a new mechanism of higher ROS production in ovarian cancer cells and provides strong evidence that endogenous ROS play an important role for cancer cells to induce angiogenesis and tumor growth. This information may be useful to understand the new mechanism of cancer cells in inducing tumorigenesis and to develop new therapeutic strategy by targeting ROS signaling in human cancer in the future.
465 citations
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TL;DR: In this paper, the mass, spin, and redshift distributions of binary black hole (BBH) mergers with LIGO and Advanced Virgo observations were analyzed using phenomenological population models.
Abstract: We present results on the mass, spin, and redshift distributions with phenomenological population models using the 10 binary black hole (BBH) mergers detected in the first and second observing runs completed by Advanced LIGO and Advanced Virgo. We constrain properties of the BBH mass spectrum using models with a range of parameterizations of the BBH mass and spin distributions. We find that the mass distribution of the more massive BH in such binaries is well approximated by models with no more than 1% of BHs more massive than 45 M and a power-law index of (90% credibility). We also show that BBHs are unlikely to be composed of BHs with large spins aligned to the orbital angular momentum. Modeling the evolution of the BBH merger rate with redshift, we show that it is flat or increasing with redshift with 93% probability. Marginalizing over uncertainties in the BBH population, we find robust estimates of the BBH merger rate density of R= (90% credibility). As the BBH catalog grows in future observing runs, we expect that uncertainties in the population model parameters will shrink, potentially providing insights into the formation of BHs via supernovae, binary interactions of massive stars, stellar cluster dynamics, and the formation history of BHs across cosmic time.
464 citations
Authors
Showing all 25957 results
Name | H-index | Papers | Citations |
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Graham A. Colditz | 261 | 1542 | 256034 |
Zhong Lin Wang | 245 | 2529 | 259003 |
Michael Kramer | 167 | 1713 | 127224 |
Gabriel Núñez | 148 | 466 | 105724 |
Darwin J. Prockop | 128 | 576 | 87066 |
Adrian Bauman | 127 | 1061 | 91151 |
Chao Zhang | 127 | 3119 | 84711 |
Robert J. Motzer | 121 | 883 | 80129 |
Mark W. Dewhirst | 116 | 797 | 57525 |
Alessandra Romero | 115 | 1143 | 69571 |
Xiaoming Li | 113 | 1932 | 72445 |
Stephen M. Davis | 109 | 675 | 53144 |
Alan Campbell | 109 | 687 | 53463 |
Steven C. Hayes | 106 | 450 | 51556 |
I. A. Bilenko | 105 | 393 | 68801 |