Institution
Zhejiang University
Education•Hangzhou, Zhejiang, China•
About: Zhejiang University is a education organization based out in Hangzhou, Zhejiang, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 161257 authors who have published 183264 publications receiving 3417592 citations. The organization is also known as: Chekiang University & Zheda.
Topics: Catalysis, Population, Computer science, Medicine, Cancer
Papers published on a yearly basis
Papers
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TL;DR: This anisotropic swelling results in lithiated Si nanowires with a remarkable dumbbell-shaped cross section, which develops due to plastic flow and an ensuing necking instability that is induced by the tensile hoop stress buildup in the lithiated shell.
Abstract: We report direct observation of an unexpected anisotropic swelling of Si nanowires during lithiation against either a solid electrolyte with a lithium counter-electrode or a liquid electrolyte with a LiCoO2 counter-electrode. Such anisotropic expansion is attributed to the interfacial processes of accommodating large volumetric strains at the lithiation reaction front that depend sensitively on the crystallographic orientation. This anisotropic swelling results in lithiated Si nanowires with a remarkable dumbbell-shaped cross section, which develops due to plastic flow and an ensuing necking instability that is induced by the tensile hoop stress buildup in the lithiated shell. The plasticity-driven morphological instabilities often lead to fracture in lithiated nanowires, now captured in video. These results provide important insight into the battery degradation mechanisms.
713 citations
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TL;DR: An ingenious design strategy for the microfabrication of complex geometric 3D mesostructures that derive from the out-of-plane buckling of an originally planar structural layout is developed.
Abstract: Complex three-dimensional (3D) structures in biology (e.g., cytoskeletal webs, neural circuits, and vasculature networks) form naturally to provide essential functions in even the most basic forms of life. Compelling opportunities exist for analogous 3D architectures in human-made devices, but design options are constrained by existing capabilities in materials growth and assembly. We report routes to previously inaccessible classes of 3D constructs in advanced materials, including device-grade silicon. The schemes involve geometric transformation of 2D micro/nanostructures into extended 3D layouts by compressive buckling. Demonstrations include experimental and theoretical studies of more than 40 representative geometries, from single and multiple helices, toroids, and conical spirals to structures that resemble spherical baskets, cuboid cages, starbursts, flowers, scaffolds, fences, and frameworks, each with single- and/or multiple-level configurations.
713 citations
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Fudan University1, Nanchang University2, Nanjing Medical University3, Harbin Medical University4, Hebei Medical University5, Peking Union Medical College6, China Medical University (PRC)7, Sun Yat-sen University8, Qingdao University9, Fujian Medical University10, Sichuan University11, Bengbu Medical College12, Fourth Military Medical University13, Tianjin Medical University Cancer Institute and Hospital14, Shanghai Jiao Tong University15, Third Military Medical University16, Zhejiang University17, Shantou University18
TL;DR: These data show that apatinib treatment significantly improved OS and PFS with an acceptable safety profile in patients with advanced gastric cancer refractory to two or more lines of prior chemotherapy.
Abstract: PurposeThere is currently no standard treatment strategy for patients with advanced metastatic gastric cancer experiencing progression after two or more lines of chemotherapy. We assessed the efficacy and safety of apatinib, a novel vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor, in patients with advanced gastric or gastroesophageal junction adenocarcinoma for whom at least two lines of prior chemotherapy had failed.Patients and MethodsThis was a randomized, double-blind, placebo-controlled phase III trial. Patients from 32 centers in China with advanced gastric or gastroesophageal junction adenocarcinoma, for whom two or more prior lines of chemotherapy had failed, were enrolled. Patients were randomly assigned to oral apatinib 850 mg or placebo once daily. The primary end points were overall (OS) and progression-free survival (PFS).ResultsBetween January 2011 and November 2012, 267 patients were enrolled. Median OS was significantly improved in the apatinib group compared with t...
711 citations
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TL;DR: The status of geminivirus species and strain demarcation is reviewed as well as providing updated isolate descriptors for a total of 672 begomovirus isolates, and several others previously classified as “strains” have been upgraded to “species”.
Abstract: Geminivirus taxonomy and nomenclature is growing in complexity with the number of genomic sequences deposited in sequence databases Taxonomic and nomenclatural updates are published at regular intervals (Fauquet et al in Arch Virol 145:1743–1761, 2000, Arch Virol 148:405–421, 2003) A system to standardize virus names, and corresponding guidelines, has been proposed (Fauquet et al in Arch Virol 145:1743–1761, 2000) This system is now followed by a large number of geminivirologists in the world, making geminivirus nomenclature more transparent and useful In 2003, due to difficulties inherent in species identification, the ICTV Geminiviridae Study Group proposed new species demarcation criteria, the most important of which being an 89% nucleotide (nt) identity threshold between full-length DNA-A component nucleotide sequences for begomovirus species This threshold has been utilised since with general satisfaction More recently, an article has been published to clarify the terminology used to describe virus entities below the species level [5] The present publication is proposing demarcation criteria and guidelines to classify and name geminiviruses below the species level Using the Clustal V algorithm (DNAStar MegAlign software), the distribution of pairwise sequence comparisons, for pairs of sequences below the species taxonomic level, identified two peaks: one at 85–94% nt identity that is proposed to correspond to “strain” comparisons and one at 92–100% identity that corresponds to “variant” comparisons Guidelines for descriptors for each of these levels are proposed to standardize nomenclature under the species level In this publication we review the status of geminivirus species and strain demarcation as well as providing updated isolate descriptors for a total of 672 begomovirus isolates As a consequence, we have revised the status of some virus isolates to classify them as “strains”, whereas several others previously classified as “strains” have been upgraded to “species” In all other respects, the classification system has remained robust, and we therefore propose to continue using it An updated list of all geminivirus isolates and a phylogenetic tree with one representative isolate per species are provided
708 citations
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TL;DR: The typical cancer‐drug‐delivery process of an intravenously administered nanomedicine is analyzed and it is concluded that the delivery involves a five‐step CAPIR cascade and that high efficiency at every step is critical to guarantee high overall therapeutic efficiency.
Abstract: Current cancer nanomedicines can only mitigate adverse effects but fail to enhance therapeutic efficacies of anticancer drugs. Rational design of next-generation cancer nanomedicines should aim to enhance their therapeutic efficacies. Taking this into account, this review first analyzes the typical cancer-drug-delivery process of an intravenously administered nanomedicine and concludes that the delivery involves a five-step CAPIR cascade and that high efficiency at every step is critical to guarantee high overall therapeutic efficiency. Further analysis shows that the nanoproperties needed in each step for a nanomedicine to maximize its efficiency are different and even opposing in different steps, particularly what the authors call the PEG, surface-charge, size and stability dilemmas. To resolve those dilemmas in order to integrate all needed nanoproperties into one nanomedicine, stability, surface and size nanoproperty transitions (3S transitions for short) are proposed and the reported strategies to realize these transitions are comprehensively summarized. Examples of nanomedicines capable of the 3S transitions are discussed, as are future research directions to design high-performance cancer nanomedicines and their clinical translations.
708 citations
Authors
Showing all 162389 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stuart H. Orkin | 186 | 715 | 112182 |
H. S. Chen | 179 | 2401 | 178529 |
Markus Antonietti | 176 | 1068 | 127235 |
Yang Yang | 171 | 2644 | 153049 |
Gang Chen | 167 | 3372 | 149819 |
Jun Wang | 166 | 1093 | 141621 |
Hua Zhang | 163 | 1503 | 116769 |
Rui Zhang | 151 | 2625 | 107917 |
Ben Zhong Tang | 149 | 2007 | 116294 |
J. Fraser Stoddart | 147 | 1239 | 96083 |
Yi Yang | 143 | 2456 | 92268 |
Jian Yang | 142 | 1818 | 111166 |
Liming Dai | 141 | 781 | 82937 |
Joseph Lau | 140 | 1048 | 99305 |
Wei Huang | 139 | 2417 | 93522 |