A review of in-vivo optical properties of human tissues and its impact on PDT
J Sandell,Timothy C. Zhu +1 more
TLDR
The overall trend of the absorption spectra as a function of wavelength within a 95% confidence interval for various tissues in vivo is examined and the impact of optical properties on light fluence rate is discussed for various light application geometries including superficial, interstitial, and within a cavity.Abstract:
A thorough understanding of optical properties of biological tissues is critical to effective treatment planning for therapies such as photodynamic therapy (PDT). In the last two decades, new technologies, such as broadband diffuse spectroscopy, have been developed to obtain in vivo data in humans that was not possible before. We found that the in vivo optical properties generally vary in the ranges μ(a) = 0.03-1.6 cm⁻¹ and μ'(s) = 1.2-40 cm⁻¹, although the actual range is tissue-type dependent. We have also examined the overall trend of the absorption spectra (for μ(a) and μ'(s)) as a function of wavelength within a 95% confidence interval for various tissues in vivo. The impact of optical properties on light fluence rate is also discussed for various light application geometries including superficial, interstitial, and within a cavity.read more
Citations
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Ex Vivo Determination of Broadband Absorption and Effective Scattering Coefficients of Porcine Tissue
TL;DR: In this article, a novel approach for precise determination of the optical scattering and absorption properties of porcine tissue using an optimized integrating sphere setup was applied, where measurements on several sample types (skin, muscle, adipose tissue, bone, cartilage, brain) in the spectral range between 400 nm and 1400 nm were performed.
Journal ArticleDOI
Laser activatable perfluorocarbon bubbles for imaging and therapy through enhanced absorption from coupled silica coated gold nanoparticles
Donald A. Fernandes,Donald A. Fernandes,Sila Appak-Baskoy,Sila Appak-Baskoy,Elizabeth S. L. Berndl,Elizabeth S. L. Berndl,Michael C. Kolios,Michael C. Kolios +7 more
Abstract: Nanoparticles have extensively been used for cancer therapy and imaging (i.e., theranostics) using various imaging modalities. Due to their physical and chemical properties (e.g., absorption, fluorescence, and magnetic properties) they have been used for image guided therapy for cancer treatment monitoring. There are various limitations that make many theranostic agents unable to be used for the extended periods of time required for enhancing theranostic capabilities. Some of these are due to inherent characteristics (e.g., change and/or breakdown of structure) present upon continuous irradiation and others are due to environmental (i.e., physiological) conditions that can lead to physical instability (i.e., in terms of size) affecting the amount of particles that can accumulate at the target site and the overall contrast that can be achieved. In this study, perfluorohexane (PFH) nanoemulsions (NEs) were synthesized with silica coated gold nanoparticles (PFH-NEs-scAuNPs) in order to give both stable and enhanced signals for cancer imaging by increasing vaporization of the emulsions into bubbles through the process of optical droplet vaporization (ODV). The resulting perfluorohexane bubbles could be imaged using nonlinear ultrasound (NL US) which significantly increases the signal to noise ratio due to the nonlinear scattering properties of oscillating bubbles. The NL US signals from PFH bubbles were found to be more stable compared to conventional bubbles used for contrast imaging. In addition, the vaporization of PFH NEs into bubbles was shown to cause significant cancer cell death reflecting the theranostic capabilities of the formed PFH bubbles. Since cell death is initiated with laser excitation of PFH-NEs-scAuNPs, these nanoparticles can specifically target cancer cells once they have accumulated at the tumor region. Due to the type of theranostic agent and imaging modality used, the PFH-NEs-scAuNPs can be used to provide higher specificity compared to other agents for locating the tumor region by minimizing tissue specific signals while at the same time being used to treat cancer.
Journal ArticleDOI
Laser-Induced Thermal Treatment of Superficial Human Tumors: An Advanced Heating Strategy and Non-Arrhenius Law for Living Tissues
TL;DR: The most interesting results obtained by the author in modeling laser-induced hyperthermia of human tumors are discussed in this article , and the advantages of this advanced strategy of soft thermal treatment (in few of sessions), which is painless for patients, are discussed as well.
Journal ArticleDOI
Guided-Mode-Resonant Dielectric Metasurfaces for Colorimetric Imaging of Material Anisotropy in Fibrous Biological Tissue
Lisa V. Poulikakos,Lisa V. Poulikakos,Mark Lawrence,David R. Barton,Stefanie S. Jeffrey,Jennifer A. Dionne +5 more
TL;DR: The structural arrangement of fibrous tissue is linked to the onset and progression of Alzheimer's disease, heart disease, fibrosis, and cancer, yet its visualization remains challenging with conve... as mentioned in this paper.
Journal ArticleDOI
Scattering of Light from the Systemic Circulatory System.
TL;DR: The basic idea of this review article is to provide the optical properties of the circulatory system with all those factors of influence that have been employed in biomedical optics for different applications.
References
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A review of the optical properties of biological tissues
TL;DR: The known optical properties (absorption, scattering, total attenuation, effective attenuation and/or anisotropy coefficients) of various biological tissues at a variety of wavelengths are reviewed in this article.
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