A study on oxidative stress biomarkers and immunomodulatory effects of pesticides in pesticide-sprayers
TLDR
Investigation of the oxidative stress and immunomodulatory effects of pesticides exposure among agricultural workers according the level of pesticide residues in their blood revealed non-significant reduction of the activity of (AchE), antioxidant defense enzymes, total antioxidant capacity, IgM and IgG while, MDA and TNF levels showed significant elevations in insecticides-exposed workers versus control.Abstract:
This work was conducted on 95 adult males from Al-Salheya Algadeeda-Sharkeya governorate. They were classified according to pesticides residues into control group (30 unexposed healthy adult males living in the same area), insecticides exposed workers group (55 adult males exposed to organophosphate and carbamates) and fungicides exposed workers group (10 adult males exposed to fungicides). The study was designed to investigate and compare the oxidative stress and immunomodulatory effects of pesticides exposure among agricultural workers according the level of pesticide residues in their blood which was measured by HPLC. The oxidative stress status has been evaluated by assessment of (SH-protein), glutathione-S-transferase (GST), glutathione reductase (GR), total antioxidant capacity and malondialdehyde (MDA). In addition, the acetylcholinesterase (AchE) activity was measured as a biomarker of toxicity. We used IgG, IgM, as immunological biomarkers to test the humoral immune function as well as TNFα as a biomarker of cellular immune function. Our result revealed statistically significant reduction of the activity of (AchE), antioxidant defense enzymes, total antioxidant capacity, IgM and IgG while, MDA and TNF levels showed significant elevations in insecticides-exposed workers versus control. Results of fungicides exposed workers revealed non-significant reduction of the activity of (AchE), antioxidant defense enzymes, IgM, IgG and TNFα levels while there was significant elevation of MDA level and significant reduction of total antioxidant capacity level.read more
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TL;DR: The protective effects of NAC against oxidative stress caused by pesticide in many organs are focused on and the possible mechanisms of action may be associated to its antioxidant properties.
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Oxidative stress and genetic damage among workers exposed primarily to organophosphate and pyrethroid pesticides.
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TL;DR: An important role of antioxidant enzymes is suggested for the protection of DNA damage caused by occupational exposure to pesticides among sprayers (workers) occupationally exposed to pesticides.
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