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Open AccessJournal ArticleDOI

Anatomy and neuro-pathophysiology of the cough reflex arc

TLDR
The anatomy and the neuro-pathophysiology of the cough reflex arc are analyzed and the anatomic and pathophysiologic elements of evaluation of the complex and multiple etiologies of cough are provided.
Abstract
Coughing is an important defensive reflex that occurs through the stimulation of a complex reflex arc. It accounts for a significant number of consultations both at the level of general practitioner and of respiratory specialists. In this review we first analyze the cough reflex under normal conditions; then we analyze the anatomy and the neuro-pathophysiology of the cough reflex arc. The aim of this review is to provide the anatomic and pathophysiologic elements of evaluation of the complex and multiple etiologies of cough.

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Journal ArticleDOI

Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part I: Headache

Hsiangkuo Yuan, +1 more
- 01 Jan 2016 - 
TL;DR: With a broad vagal neural network, VNS may exert a neuromodulatory effect to activate certain innate “protective” pathways for restoring health.
Proceedings ArticleDOI

Coswara - A database of breathing, cough, and voice sounds for COVID-19 diagnosis

TL;DR: In this article, the authors present an early effort in creating (and analyzing) a database, called Coswara, of respiratory sounds, namely, cough, breath, and voice, collected via worldwide crowdsourcing using a website application.
Journal ArticleDOI

Cough in idiopathic pulmonary fibrosis

TL;DR: The different theories regarding the pathophysiology of cough are described, the different methods to assess cough are reviewed, and the recent and future developments in the treatment of cough in IPF are dealt with.
References
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Journal ArticleDOI

Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology.

TL;DR: A 4-day trial of withdrawal of the ACE inhibitor or temporary substitution of another class of antihypertensive agent inexpensively and easily ascertains if the ACE inhibitors caused the cough is easily ascertained.
Journal ArticleDOI

Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy.

TL;DR: It is concluded that the anatomic diagnostic protocol for evaluating patients with chronic cough is still valid and that it has well-defined strengths and limitations.
Book ChapterDOI

Afferent vagal C fibre innervation of the lungs and airways and its functional significance

TL;DR: This review has attempted to give an account of an afferent vagal input from the lower respiratory tract that has still to be explored fully, and to present experimental evidence that this fine fibre afferent system plays a significant role in the neural control of respiratory function in both normal and pathological circumstances.
Journal ArticleDOI

Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy.

TL;DR: Using an anatomic, diagnostic protocol, the cause of chronic persistent cough can be consistently determined and postnasal drip and/or bronchial asthma are very common causes of cough.
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