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Journal ArticleDOI

Autoimmune hemolytic anemia

TLDR
This review discusses the demographics, etiology, clinical presentation, laboratory evaluation, and treatment options of autoimmune hemolytic anemia, which includes warm AIHA, cold agglutinin syndrome, paroxysmal cold hemoglobinuria, mixed‐type AIH, and drug‐induced AIHA.
Abstract
Red blood cell (RBC) autoantibodies are a relatively uncommon cause of anemia. However, autoimmune hemolytic anemia (AIHA) must be considered in the differential diagnosis of hemolytic anemias, especially if the patient has a concomitant lymphoproliferative disorder, autoimmune disease, or viral or mycoplasmal infection. Classifications of AIHA include warm AIHA, cold agglutinin syndrome, paroxysmal cold hemoglobinuria, mixed-type AIHA, and drug-induced AIHA. Characteristics of the autoantibodies are responsible for the various clinical entities. As a result, diagnosis is based on the clinical presentation and a serologic work-up. For each classification of AIHA, this review discusses the demographics, etiology, clinical presentation, laboratory evaluation, and treatment options.

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Citations
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Journal ArticleDOI

Association of Schizophrenia and Autoimmune Diseases: Linkage of Danish National Registers

TL;DR: Schizophrenia is associated with a larger range of autoimmune diseases than heretofore suspected and future research on comorbidity has the potential to advance understanding of pathogenesis of both psychiatric and autoimmune disorders.
Journal ArticleDOI

How I treat autoimmune hemolytic anemias in adults

TL;DR: Currently, splenectomy can be regarded as the most effective and best-evaluated second-line therapy, but there are still only limited data on long-term efficacy and adverse effects.
Journal ArticleDOI

The SARS-CoV-2 as an instrumental trigger of autoimmunity.

TL;DR: In this paper, the authors focused on the association between COVID-19 and the immune system concerning the tendency of patients to develop over 15 separate types of autoantibodies and above 10 distinct autoimmune diseases.
References
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Journal ArticleDOI

The role of membrane receptors for C3b and C3d in phagocytosis.

TL;DR: It is concluded that two fragments of the C3 molecule, that is, C3b and C3d, can function as opsonins if the phagocyte has the appropriate membrane receptors.
Journal ArticleDOI

Red cells coated with immunoglobulin G: binding and sphering by mononuclear cells in man.

TL;DR: It is inferred that mononuclear cells have specific surface receptors for immunoglobulin G and that these provide a critical phase of the mechanism in vivo, whereby red cells or other particles coated with antibody are apprehended and destroyed.
Journal ArticleDOI

Primary thrombocytopenic purpura and acquired hemolytic anemia; evidence for a common etiology.

TL;DR: Reports of transitory thrombocytopenia in infants of women with throm bocytopenic purpura are of particular interest, since these cases suggest that an agent producing the throma is transmissible through the placenta.
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