Journal ArticleDOI
Biological effects of cyclosporin A: A new antilymphocytic agent
TLDR
Experimental evidence suggests that cyclosporin A affects an early stage of mitogenic triggering of the immunocompetent lymphoid cell, which contrasts with other immunosuppressives and cytostatic drugs in its weak myelotoxicity.Abstract:
The fungus metabolite cyclosporin A is a small peptide acting as a novel antilymphocytic agent. It strongly depressed appearance of both direct and indirect plaque-forming cells and produced a clear dose-dependent inhibition of haemagglutinin formation in mice upon oral administration. Skin graft rejection in mice and graft-versus-host disease in mice and rats were considerably delayed by cyclosporin A which also prevented the occurrence of paralysis in rats with experimental allergic encephalomyelitis. This compound was not only highly effective in preventing development of Freund's adjuvant arthritis, but in addition improved the symptoms in rats with established arthritis, although it is inactive in acute inflammation. This new agent contrasts with other immunosuppressives and cytostatic drugs in its weak myelotoxicity. Experimental evidence suggests that cyclosporin A, rather than being cytostatic or lympholytic, affects an early stage of mitogenic triggering of the immunocompetent lymphoid cell.read more
Citations
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The mechanism of action of cyclosporin A and FK506
TL;DR: Recent findings that indicate CsA and FK506 operate as prodrugs are reviewed: they bind endogenous intracellular receptors, the immunophilins, and the resulting complex targets the protein phosphatase, calcineurin, to exert the immunosuppressive effect.
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Immunosuppressive Drugs for Kidney Transplantation
TL;DR: This review considers the use of immunosuppressive drugs in organ transplantation, focusing on renal transplantation.
Journal ArticleDOI
Mycophenolate mofetil and its mechanisms of action.
TL;DR: The efficacy of regimes including CellCept(R) in preventing allograft rejection, and in the treatment of rejection, is now firmly established and it is hoped that the drug will have the same effect in humans.
Journal ArticleDOI
Platforms for antibiotic discovery
TL;DR: Strategies to re-establish viable platforms for antibiotic discovery include investigating untapped natural product sources such as uncultured bacteria, establishing rules of compound penetration to enable the development of synthetic antibiotics, developing species-specific antibiotics and identifying prodrugs that have the potential to eradicate dormant persisters, which are often responsible for hard-to-treat infections.
Journal ArticleDOI
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A.
TL;DR: NF-AT is formed when a signal from the antigen receptor induces a pre-existing cytoplasmic subunit to translocate to the nucleus and combine with a newly synthesized nuclear subunit of NF-AT, forming a inhibitory complex between the drug and isomerase.
References
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Journal ArticleDOI
The Technique of Free Skin Grafting in Mammals
TL;DR: Methods are described for the execution of free skin grafts in rabbits, guinea-pigs and mice and use has been made of the techniques described above.
Journal ArticleDOI
[Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity].
Artur Rüegger,Max Kuhn,Heinz Lichti,Hans-Rudolf Loosli,René Huguenin,Charles Quiquerez,Albert Von Wartburg +6 more
TL;DR: The complete structure of cyclosporin A was elucidated as the neutral cyclic oligopeptide 1, which show remarkable immunosuppressive and antiphlogistic activities in several pharmacological models.
Journal ArticleDOI
The Use of Spiral Loops in Serological and Virological Micro-Methods
TL;DR: An article of historical interest, and of general importance, is reprinted in the present volume accompanied by current editorial notes.
Journal ArticleDOI
Treatment of adjuvant arthritis in rats with anti-inflammatory drugs.
Charles A. Winter,George W. Nuss +1 more
Journal ArticleDOI
Phase-Contrast Microscopy
C R Burch,J P P Stock +1 more
TL;DR: A simple method of adapting an ordinary microscope for phase-contrast illumination is described, together with the preparation of a test-slide to check its performance, and has proved helpful in studies of the interaction between leucocytes and mobile organisms.