Journal ArticleDOI
Bone tissue regeneration: the role of scaffold geometry
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TLDR
Recent discoveries concerning the effects of geometrical features of porous scaffolds such as surface curvature, pore shape, and pore size on the cellular response and bone tissue regeneration process are reviewed and recommended for future research.Abstract:
The geometry of porous scaffolds that are used for bone tissue engineering and/or bone substitution has recently been shown to significantly influence the cellular response and the rate of bone tissue regeneration. Most importantly, it has been shown that the rate of tissue generation increases with curvature and is much larger on concave surfaces as compared to convex and planar surfaces. In this work, recent discoveries concerning the effects of geometrical features of porous scaffolds such as surface curvature, pore shape, and pore size on the cellular response and bone tissue regeneration process are reviewed. In addition to reviewing the recent experimental observations, we discuss the mechanisms through which geometry affects the bone tissue regeneration process. Of particular interest are the theoretical models that have been developed to explain the role of geometry in the bone tissue regeneration process. We then follow with a section on the implications of the observed phenomena for geometrical design of porous scaffolds including the application of predictive computational models in geometrical design of porous scaffolds. Moreover, some geometrical concepts in the design of porous scaffolds such as minimal surfaces and porous structures with geometrical gradients that have not been explored before are suggested for future studies. We especially focus on the porous scaffolds manufactured using additive manufacturing techniques where the geometry of the porous scaffolds could be precisely controlled. The paper concludes with a general discussion of the current state-of-the-art and recommendations for future research.read more
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Journal ArticleDOI
SLM lattice structures: Properties, performance, applications and challenges
Tobias Maconachie,Tobias Maconachie,Martin Leary,Martin Leary,Bill Lozanovski,Xuezhe Zhang,Ma Qian,Omar Faruque,Omar Faruque,Milan Brandt +9 more
TL;DR: A comprehensive summary of the experimental data reported on the mechanical response of Selective Laser Melting (SLM) lattice structures can be found in this paper, where the design, fabrication and performance of SLM lattice structure are reviewed and the quality of data reported to inform best-practice for future studies.
Journal ArticleDOI
Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment.
Naoya Taniguchi,Shunsuke Fujibayashi,Mitsuru Takemoto,Kiyoyuki Sasaki,Bungo Otsuki,Takashi Nakamura,Tomiharu Matsushita,Tadashi Kokubo,Shuichi Matsuda +8 more
TL;DR: The results indicate that the pore structure of the P600 implant is a suitable porous structure for orthopedic implants manufactured by SLM.
Journal ArticleDOI
Additively manufactured metallic porous biomaterials based on minimal surfaces: A unique combination of topological, mechanical, and mass transport properties
F. S. L. Bobbert,Karel Lietaert,Ali Eftekhari,Behdad Pouran,S.M. Ahmadi,Harrie Weinans,Amir A. Zadpoor +6 more
TL;DR: Rationally designed and additively manufactured porous metallic biomaterials based on four different types of triply periodic minimal surfaces that mimic the properties of bone to an unprecedented level of multi-physics detail exhibit an interesting combination of topological, mechanical, and mass transport properties.
Journal ArticleDOI
3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy.
TL;DR: 3D-printed bioceramic scaffolds with different compositions and hierarchical structures (macro, micro, and nano scales), and their effects on the mechanical, degradation, permeability, and biological properties are focused on.
Journal ArticleDOI
Additive Manufacturing of Biomaterials, Tissues, and Organs
Amir A. Zadpoor,Jos Malda +1 more
TL;DR: This editorial aims to sketch the research landscape within which the other contributions of the special issue can be better understood and positioned and review the most important areas of biomedical research and clinical practice that have benefited from recent developments in additive manufacturing techniques.
References
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