British Thoracic Society Guideline for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)
Charles S. Haworth,John Banks,Toby Capstick,Andrew J. Fisher,Thomas Gorsuch,Ian F Laurenson,Andrew R. Leitch,Michael R. Loebinger,Heather Milburn,Mark Nightingale,Peter Ormerod,Delane Shingadia,David Smith,Nuala Whitehead,Robert Wilson,R. Andres Floto +15 more
TLDR
The full guideline for the management of non-tuberculous mycobacterial pulmonary disease is published in Thorax and a summary of the recommendations and good practice points is provided.Abstract:
The full guideline for the management of non-tuberculous mycobacterial pulmonary disease is published in Thorax. The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline.read more
Citations
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Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Josephine M. Bryant,Dorothy M Grogono,Daniela Rodriguez-Rincon,Isobel Everall,Karen Brown,Pablo Moreno,Deepshikha Verma,E. Hill,J. Drijkoningen,Peter H. Gilligan,Charles R. Esther,Peadar G. Noone,Olivia Giddings,Scott C. Bell,Rachel Thomson,Claire E. Wainwright,Chris Coulter,Sushil Pandey,Michelle Wood,Rebecca E Stockwell,Kay A. Ramsay,Laura J. Sherrard,Timothy J. Kidd,Nassib Jabbour,Graham R. Johnson,Luke D. Knibbs,Lidia Morawska,Peter D. Sly,Alison Jones,Diana Bilton,Ian F. Laurenson,Michael Ruddy,Stephen Bourke,Ian C. J. W. Bowler,Stephen J Chapman,Andrew Clayton,M. Cullen,Owen J. Dempsey,Miles Denton,M. Desai,R. J. Drew,F. Edenborough,Jason T. Evans,Jonathan Folb,T. Daniels,H. Humphrey,B. Isalska,Søren Jensen-Fangel,Bodil Jönsson,Andrew Jones,Terese L. Katzenstein,Troels Lillebaek,Gordon MacGregor,S. Mayell,Michael Millar,Deborah E. Modha,Edward F. Nash,C. O'Brien,D. OBrien,Chandra Ohri,Caroline S. Pao,Daniel Peckham,Felicity Perrin,Audrey Perry,Tacjana Pressler,L. Prtak,Tavs Qvist,A. Robb,Helen Rodgers,K. Schaffer,Nadia Shafi,J. van Ingen,M. Walshaw,D. Watson,Noreen West,Joanna L. Whitehouse,Charles S. Haworth,Simon R. Harris,Diane J. Ordway,Julian Parkhill,R.A. Floto +80 more
TL;DR: In this paper, the authors used whole-genome analysis of a global collection of clinical isolates to show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones.
Journal ArticleDOI
The Rise of Non-Tuberculosis Mycobacterial Lung Disease
Champa N. Ratnatunga,Viviana P. Lutzky,Andreas Kupz,Andreas Kupz,Denise L. Doolan,Denise L. Doolan,David W. Reid,Matthew A. Field,Matthew A. Field,Scott C. Bell,Rachel Thomson,John J. Miles,John J. Miles +12 more
TL;DR: The incidence and number of deaths from non-tuberculous mycobacterial (NTM) disease have been steadily increasing globally and due to climate change, the Tropics are expanding which will increase NTM infection regions.
Journal ArticleDOI
The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance.
TL;DR: Better knowledge of the underlying mechanisms of drug resistance in M. abscessus could improve selection of more effective chemotherapeutic regimen and promote development of novel antimicrobials which can overwhelm the existing resistance mechanisms.
Journal ArticleDOI
Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement
Jakko van Ingen,Timothy R. Aksamit,Claire Andrejak,Erik C. Böttger,Emmanuelle Cambau,Charles L. Daley,David E. Griffith,Lorenzo Guglielmetti,Steven M. Holland,Gwen A. Huitt,Won-Jung Koh,Christoph Lange,Philip Leitman,Theodore K. Marras,Kozo Morimoto,Kenneth N. Olivier,Miguel Santin,Jason E. Stout,Rachel Thomson,Enrico Tortoli,Richard J. Wallace,Kevin L. Winthrop,Dirk Wagner +22 more
TL;DR: Treatment outcome reporting in NTM disease needs to be improved, and a consensus statement on treatment outcome definitions is needed.
Journal ArticleDOI
Incidence and prevalence of nontuberculous mycobacterial lung disease in a Large U.S. Managed Care Health Plan, 2008-2015
TL;DR: The incidence and prevalence of NTM lung disease appears to be increasing in the United States, particularly among women and older age groups, and overall at the national level.
References
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Journal ArticleDOI
An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.
David E. Griffith,Timothy R. Aksamit,Barbara A. Brown-Elliott,Antonino Catanzaro,Charles L. Daley,Fred M. Gordin,Steven M. Holland,Robert Horsburgh,Gwen A. Huitt,Michael F. Iademarco,Michael D. Iseman,Kenneth N. Olivier,Stephen J. Ruoss,C. Fordham von Reyn,Richard J. Wallace,Kevin L. Winthrop +15 more
TL;DR: Diagnostic Criteria of Nontuberculous Mycobacterial Lung Disease Key Laboratory Features of N TM Health Careand Hygiene-associated Disease Prevention Prophylaxis and Treatment of NTM Disease Introduction Methods.
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Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis.
TL;DR: A method for the rapid identification of mycobacteria to the species level was developed on the basis of evaluation by the polymerase chain reaction (PCR) of the gene encoding for the 65-kDa protein.
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Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness.
Toni R. Prezant,J V Agapian,M C Bohlman,Xiangdong Bu,S Oztas,W Q Qiu,K S Arnos,Gino A Cortopassi,Lutfi Jaber,Jerome I. Rotter +9 more
TL;DR: This study offers the first description of a mitochondrial rRNA mutation leading to disease, the first cases of non–syndromic deafness caused by a mitochondrial DNA mutation and the first molecular genetic study of antibiotic–induced ototoxicity.
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A consensus document for the selection of lung transplant candidates: 2014-An update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation
David Weill,Christian Benden,Paul A. Corris,John H. Dark,R. Duane Davis,Shaf Keshavjee,David J. Lederer,Michael J. Mulligan,G. Alexander Patterson,Lianne G. Singer,Greg Snell,Geert Verleden,Martin R. Zamora,Allan R. Glanville +13 more
TL;DR: Recommendations include discussions not present in previous ISHLT guidelines, including lung allocation scores, bridging to transplant with mechanical circulatory and ventilator support, and expanded indications for lung transplantation.
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Azithromycin and the risk of cardiovascular death.
TL;DR: There was a small absolute increase in cardiovascular deaths, which was most pronounced among patients with a high baseline risk of cardiovascular disease and patients in the highest decile of risk for cardiovascular disease.
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