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Open AccessJournal ArticleDOI

Developmental dysplasia of the hip

TLDR
Treatment of developmental dysplasia of the hip depends on age at presentation and outcomes are much better when the child is treated early, particularly during the first six months of life.
Abstract
Developmental dysplasia of the hip (DDH) is a spectrum of anatomical abnormalities of the hip joint in which the femoral head has an abnormal relationship with the acetabulum. Most studies report an incidence of 1 to 34 cases per 1,000 live births and differences could be due to different diagnostic methods and timing of evaluation. Risk factors include first born status, female sex, positive family history, breech presentation and oligohydramnios. Clinical presentations of DDH depend on the age of the child. Newborns present with hip instability, infants have limited hip abduction on examination, and older children and adolescents present with limping, joint pain, and/or osteoarthritis. Repeated, careful examination of all infants from birth and throughout the first year of life until the child begins walking is important to prevent late cases. Provocative testing includes the Barlow and Ortolani maneuvers. Other signs, such as shorting of the femur with hips and knees flexed (Galeazzi sign), asymmetry of the thigh or gluteal folds, and discrepancy of leg lengths are potential clues. Treatment depends on age at presentation and outcomes are much better when the child is treated early, particularly during the first six months of life.

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Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model.

TL;DR: SMSC-140-Exos enhanced the proliferation and migration of ACs without damaging ECM secretion in vitro, while in vivo, SMSC- 140- exos successfully prevented OA in a rat model.
Journal ArticleDOI

The Epidemiology and Demographics of Hip Dysplasia

TL;DR: Predictors of developmental dysplasia of the hip are breech presentation, positive family history, and gender (female), and certain HLA A, B, and D types demonstrate an increase in DDH, both in the northern and southern hemispheres, and swaddling is strongly associated with DDH.
Journal ArticleDOI

Developmental dysplasia of the hip: What has changed in the last 20 years?

TL;DR: The current practice for detection and treatment of DDH is summarized, emphasizing updates in screening and treatment during the last two decades.
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Risk factors for developmental dysplasia of the hip: a meta-analysis

TL;DR: A systematic review and meta-analysis of the available evidence on DDH risk factors shows that infants born in breech presentation, female infants, infants with a positive family history and clicking hips at clinical examination have an increased risk for DDH.
Journal ArticleDOI

Reliability of a New Radiographic Classification for Developmental Dysplasia of the Hip.

TL;DR: The IHDI method of classification has excellent inter-rater reliability, both among experts and novices, and is more widely applicable than the Tönnis method as it can be applied even when the ossification centre is absent.
References
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Journal ArticleDOI

ACETABULAR DYSPLASIA AND FAMILIAL JOINT LAXITY: TWO ETIOLOGICAL FACTORS IN CONGENITAL DISLOCATION OF THE HIP: A Review of 589 Patients and Their Families

TL;DR: In this article, a survey of genetic and other etiological factors has been carried out in 589 index patients with congenital dislocation of the hip and their families, with special investigation of acetabular dysplasia, familial joint laxity and a comparison of neonatal and late-diagnosis cases.
Journal ArticleDOI

Developmental dysplasia of the hip.

TL;DR: High quality studies of the adult outcomes of developmental hip dysplasia and the childhood origins of early degenerative hip disease are needed, as are randomised trials to assess the effectiveness and safety of neonatal screening and early treatment.
Journal ArticleDOI

Closed reduction for congenital dysplasia of the hip. Functional and radiographic results after an average of thirty years

TL;DR: Despite generally good function at the latest follow-up evaluation, the prognosis for these patients remained guarded, as function tended to deteriorate with time, even in the absence of disturbance of growth in the proximal end of the femur.
Journal ArticleDOI

Developmental Dysplasia of the Hip: A New Approach to Incidence

TL;DR: The implementation of this protocol enables us to distinguish two categories of neonatal hip pathology: one that eventually develops into a normal hip (essentially sonographic DDH); and another that will deteriorate into a hip with some kind of dysplasia, including full dislocation (true DDH).
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