Institution
Southampton General Hospital
Healthcare•Southampton, Southampton, United Kingdom•
About: Southampton General Hospital is a healthcare organization based out in Southampton, Southampton, United Kingdom. It is known for research contribution in the topics: Population & Asthma. The organization has 7597 authors who have published 9925 publications receiving 546600 citations.
Topics: Population, Asthma, Pregnancy, Birth weight, Histamine
Papers published on a yearly basis
Papers
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TL;DR: The evidence for adverse effects on health of selected air pollutants is discussed, and it is unclear whether a threshold concentration exists for particulate matter and ozone below which no effect on health is likely.
4,010 citations
University Hospital Bonn1, University of California, Riverside2, Harvard University3, Case Western Reserve University4, University of Illinois at Chicago5, European Institute6, VA Palo Alto Healthcare System7, Stanford University8, Spanish National Research Council9, Cleveland Clinic Lerner Research Institute10, Hong Kong University of Science and Technology11, University of California, Los Angeles12, University of Southern Denmark13, University of Cambridge14, Ikerbasque15, University of Manchester16, University of the Basque Country17, RIKEN Brain Science Institute18, University of Eastern Finland19, University of Bonn20, University of Massachusetts Medical School21, Center of Advanced European Studies and Research22, University of Southern California23, University of South Florida24, Duke University25, Southampton General Hospital26, Moorgreen Hospital27, University of Southampton28, Louisiana State University29, Imperial College London30, Centre national de la recherche scientifique31, Karolinska Institutet32, Max Planck Society33, University of Tübingen34, University of Groningen35, University of Colorado Denver36, Douglas Mental Health University Institute37
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Abstract: Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease.
3,947 citations
TL;DR: Measurements that promote prenatal and postnatal growth may reduce deaths from ischaemic heart disease and may be especially important in boys who weigh below 7.5 pounds (3.4 kg) at birth.
3,214 citations
TL;DR: It is proposed that one of the major long-term consequences of inadequate early nutrition is impaired development of the endocrine pancreas and a greatly increased susceptibility to the development of Type 2 diabetes.
Abstract: In this contribution we put forward a novel hypothesis concerning the aetiology of Type 2 (non-insulin dependent) diabetes mellitus. The concept underlying our hypothesis is that poor foetal and early post-natal nutrition imposes mechanisms of nutritional thrift upon the growing individual. We propose that one of the major long-term consequences of inadequate early nutrition is impaired development of the endocrine pancreas and a greatly increased susceptibility to the development of Type 2 diabetes. In the first section we outline our research which has led to this hypothesis. We will then review the relevant literature. Finally we show that the hypothesis suggests a reinterpretation of some findings and an explanation of others which are at present not easy to understand.
3,107 citations
TL;DR: In this paper, the authors sequenced the Ig V(H) genes of the tumor cells of 84 patients with CLL and correlated their findings with clinical features, finding that the lack of somatic mutation and trisomy 12 was associated with a less favorable prognosis.
2,704 citations
Authors
Showing all 7606 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Nicholas J. Wareham | 212 | 1657 | 204896 |
| Cyrus Cooper | 204 | 1869 | 206782 |
| Peter J. Barnes | 194 | 1530 | 166618 |
| David J.P. Barker | 148 | 446 | 99373 |
| Debbie A Lawlor | 147 | 1114 | 101123 |
| Stephen T. Holgate | 142 | 870 | 82345 |
| Stephen O'Rahilly | 138 | 520 | 75686 |
| David Price | 138 | 1687 | 93535 |
| Clive Osmond | 131 | 588 | 84694 |
| Philip C. Calder | 125 | 747 | 59110 |
| Kian Fan Chung | 116 | 815 | 52609 |
| Peter J. Ratcliffe | 112 | 371 | 66588 |
| Richard S. Houlston | 110 | 768 | 50101 |
| Leonardo M. Fabbri | 109 | 566 | 60838 |
| John D. Pickard | 107 | 628 | 42479 |