Dopamine signaling in reward-related behaviors
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TLDR
The role of the DA system in drug addiction and food motivation is focused on, with an overview of the role of D1 and D2 receptors in the control of reward-associated behaviors.Citations
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
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Dopamine: Functions, Signaling, and Association with Neurological Diseases
Marianne O. Klein,Daniella S. Battagello,Ariel R. Cardoso,David N. Hauser,Jackson C. Bittencourt,Ricardo G. Correa +5 more
TL;DR: The aspects of dopamine as a catecholaminergic neurotransmitter and dopamine signaling pathways elicited through dopamine receptor activation in normal brain function are summarized and the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system are described.
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The ins and outs of the striatum: role in drug addiction.
TL;DR: The use of new technologies, including optogenetics and DREADDs (Designer Receptors Exclusively Activated by Designer Drugs), are reviewed in unraveling the role of the striatum in addiction, focusing on the roles of striatal cell populations and dopaminergic and glutamatergic afferents in addiction-related plasticity and behaviors.
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An Integrative Model of the Maturation of Cognitive Control
TL;DR: In this paper, a model of the brain basis of the development of cognitive control is proposed, which provides a novel understanding of the adolescent period as an adaptive period of heightened experience-seeking.
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
Michelle D. Wang,H. Yin,R. Landick,J. Gelles,L. S. Churchman,Z. Okten,R. S. Rock,J. F. Dawson,J. A. Spudich,C. G. Baumann,S. B. Smith,V. A. Bloomfield,C. Bustamante,A. R. Dunn,D. R. Halpin,D. Herschlag,W. L. Martin,B. H. Robinson,J. M. Schurr,A. L. Smith,R. M. Weisinger,S. J. Wrenn,Y. Bai,S. Doniach,K. Ito,J. Lipfert,I. S. Millett,S. Seifert,P. Thiyagarajan,H. Tsuruta +29 more
References
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
The neural basis of drug craving: An incentive-sensitization theory of addiction
TL;DR: S sensitization of incentive salience can produce addictive behavior even if the expectation of drug pleasure or the aversive properties of withdrawal are diminished and even in the face of strong disincentives, including the loss of reputation, job, home and family.
Journal ArticleDOI
Mammalian MAP kinase signalling cascades
Lufen Chang,Michael Karin +1 more
TL;DR: Recent studies have begun to shed light on the physiological functions of MAPK cascades in the control of gene expression, cell proliferation and programmed cell death.
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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
TL;DR: It is suggested that dopamine may be more important to incentive salience attributions to the neural representations of reward-related stimuli and is a distinct component of motivation and reward.
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Multiple receptors for dopamine.
John W. Kebabian,Donald B. Calne +1 more
TL;DR: Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.