Fibronectin at a glance.
Roumen Pankov,Kenneth M. Yamada +1 more
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Fibronectin mediates a wide variety of cellular interactions with the extracellular matrix (ECM) and plays important roles in cell adhesion, migration, growth and differentiation.Abstract:
Fibronectin (FN) mediates a wide variety of cellular interactions with the extracellular matrix (ECM) and plays important roles in cell adhesion, migration, growth and differentiation ( [Mosher, 1989][1]; [Carsons, 1989][2]; [Hynes, 1990][3]; [Yamada and Clark, 1996][4]). FN is widely expressed byread more
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The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
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Local force and geometry sensing regulate cell functions.
Viola Vogel,Michael P. Sheetz +1 more
TL;DR: Tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms of eukaryotic cells.
Journal ArticleDOI
Extracellular matrix structure.
TL;DR: The complex ECM structure is emphasized as to provide a better understanding of its dynamic structural and functional multipotency and the implication of the various families of ECM macromolecules in health and disease is presented.
Journal ArticleDOI
Extracellular matrix dynamics in development and regenerative medicine.
TL;DR: Stem cell self-renewal and differentiation is influenced by the 3D environment within the stem cell niche, and the intimate dynamic relationship between cells and the ECM must be understood to ensure appropriate cell behavior.
Journal ArticleDOI
Cell–matrix adhesion
TL;DR: This mini review discusses the roles of matrix properties such as composition, three‐dimensionality, and porosity, the bi‐directional functions of cellular contractility and matrix rigidity, and cell signaling in the formation of cell adhesions, assembly of matrix, migration, and tumorigenesis and speculates on the application of this knowledge to potential future therapeutic approaches.
References
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Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.
TL;DR: This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.
Book
The Molecular and Cellular Biology of Wound Repair
Richard A.F. Clark,P. M. Henson +1 more
TL;DR: Wound Repair: Overview and General Considerations (R.A.F. Clark), Macrophage Involvement in Wound Repair, Remodeling and Fibrosis, and the Role of Plateletderived Growth Factor in vivo (C.W. Riches).
Journal ArticleDOI
Ligand binding to integrins.
TL;DR: The number of integrins and the remarkable breadth of their cellular distribution support the statement that the phenotype of virtually every cell is uniquely influenced by its display ofintegrins.
Journal ArticleDOI
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
Elizabeth L. George,Elisabeth N. Georges-Labouesse,Ramila S. Patel-King,Helen Rayburn,Richard O. Hynes +4 more
TL;DR: Mice generated in which the fibronectin gene is inactivated display shortened anterior-posterior axes, deformed neural tubes and severe defects in mesodermally derived tissues, proving that fibronECTin is required for embryogenesis.
Journal ArticleDOI
Type I collagen is thermally unstable at body temperature.
TL;DR: The data support an earlier hypothesis that in fibers collagen helices may melt and refold locally when needed, giving fibers their strength and elasticity and argue that initial microunfolding of their least stable domains would trigger self-assembly of fibers where the helices are protected from complete unfolding.