Formation and Function of the Myofibroblast during Tissue Repair
TLDR
Intervention with myofibroblast stress perception and transmission offers novel strategies to reduce tissue contracture; stress release leads to the instant loss of contraction and promotes apoptosis.About:
This article is published in Journal of Investigative Dermatology.The article was published on 2007-03-01 and is currently open access. It has received 1455 citations till now. The article focuses on the topics: Myofibroblast & Wound healing.read more
Citations
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Wound Repair and Regeneration
J.M. Reinke,H. Sorg +1 more
TL;DR: This review focuses on the healing processes of the skin and highlights the classical wound healing phases and the physiological endpoint of mammalian wound repair displays the formation of a scar, which is directly linked to the extent of the inflammatory process throughout wound healing.
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Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
TL;DR: The history of investigations into pericytes, the mural cells of blood microvessels, are reviewed, emerging concepts are indicated, and problems and promise are pointed out.
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Biomarkers for epithelial-mesenchymal transitions
Michael Zeisberg,Eric G. Neilson +1 more
TL;DR: It is believed that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype.
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The Myofibroblast: One Function, Multiple Origins
Boris Hinz,Sem H. Phan,Victor J. Thannickal,Andrea Galli,Marie-Luce Bochaton-Piallat,Giulio Gabbiani +5 more
TL;DR: A better knowledge of the molecular mechanisms conducive to the appearance of differentiated myofibroblasts in each pathological situation will be useful for the understanding of fibrosis development in different organs and the planning of strategies aiming at their prevention and therapy.
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Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
TL;DR: It is established that myofibroblast contraction functions as a mechanism to directly activate TGF-β1 from self-generated stores in the extracellular matrix (ECM), restricting autocrine generation of my ofibroblasts to a stiffened ECM.
References
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Book
Biomechanics: Mechanical Properties of Living Tissues
Yuan-Cheng Fung,Richard Skalak +1 more
TL;DR: This chapter discusses the mechanics of Erythrocytes, Leukocytes, and Other Cells, and their role in Bone and Cartilage, and the properties of Bioviscoelastic Fluids, which are a by-product of these cells.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
Rik Derynck,Ying E. Zhang +1 more
TL;DR: Transforming growth factor-β (TGF-β) proteins regulate cell function, and have key roles in development and carcinogenesis, and combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smadracing proteins, and cooperation with sequence-specific transcription factors allow substantial versatility and diversification of TGF- β family responses.
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Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.