Heavy Metal Poisoning and Cardiovascular Disease
Eman M. Alissa,Gordon A. Ferns +1 more
TLDR
A brief summary of heavy metals homeostasis is given, followed by a description of the available evidence for their link with CVD and the proposed mechanisms of action by which their toxic effects might be explained, and suspected interactions between genetic, nutritional and environmental factors are discussed.Abstract:
Cardiovascular disease (CVD) is an increasing world health problem. Traditional risk factors fail to account for all deaths from CVD. It is mainly the environmental, dietary and lifestyle behavioral factors that are the control keys in the progress of this disease. The potential association between chronic heavy metal exposure, like arsenic, lead, cadmium, mercury, and CVD has been less well defined. The mechanism through which heavy metals act to increase cardiovascular risk factors may act still remains unknown, although impaired antioxidants metabolism and oxidative stress may play a role. However, the exact mechanism of CVD induced by heavy metals deserves further investigation either through animal experiments or through molecular and cellular studies. Furthermore, large-scale prospective studies with follow up on general populations using appropriate biomarkers and cardiovascular endpoints might be recommended to identify the factors that predispose to heavy metals toxicity in CVD. In this review, we will give a brief summary of heavy metals homeostasis, followed by a description of the available evidence for their link with CVD and the proposed mechanisms of action by which their toxic effects might be explained. Finally, suspected interactions between genetic, nutritional and environmental factors are discussed.read more
Citations
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Prevalence of exposure of heavy metals and their impact on health consequences
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Protective effect of curcumin against heavy metals-induced liver damage.
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Arsenic exposure and cardiovascular disease: an updated systematic review.
TL;DR: The evidence for a causal association between high-chronic arsenic exposure and clinical cardiovascular endpoints is strengthened and additional high quality studies are needed at low-moderate arsenic levels.
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Cadmium-Induced Pathologies: Where Is the Oxidative Balance Lost (or Not)?
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Clinical and molecular aspects of lead toxicity: An update
TL;DR: The molecular basis of lead exposure resulting in various systemic effects is being extensively explored, and many genetic targets are identified, but their possible mechanisms are still an area to be explored.
References
More filters
Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal ArticleDOI
Beyond cholesterol, modifications of low-density lipoprotein that increase its atherogenicity
Journal ArticleDOI
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2007 Update A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Wayne D. Rosamond,Katherine M. Flegal,Gary Friday,Karen L. Furie,Alan S. Go,Kurt J. Greenlund,Nancy Haase,Michael Ho,Virginia J. Howard,Bret Kissela,Steven J. Kittner,Donald M. Lloyd-Jones,Mary M. McDermott,James B. Meigs,Claudia S. Moy,Graham Nichol,Christopher J. O'Donnell,Véronique L. Roger,John S. Rumsfeld,Paul D. Sorlie,Julia Steinberger,Thomas Thom,Sylvia Wasserthiel-Smoller,Yuling Hong +23 more
TL;DR: This chapter describes the most important sources and the types of data the AHA uses from them and other government agencies to derive the annual statistics in this Update.