Lack of Improvement in Renal Allograft Survival Despite a Marked Decrease in Acute Rejection Rates Over the Most Recent Era
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TLDR
This work analyzed data provided by the Scientific Registry of Transplant Recipients regarding all adult first renal transplants between 1995 and 2000 to investigate how acute rejection rates have evolved on a national level in the U.S and how this has impacted graft survival in the most recent era of kidney transplantation.About:
This article is published in American Journal of Transplantation.The article was published on 2004-03-01 and is currently open access. It has received 1157 citations till now. The article focuses on the topics: Transplantation & Kidney surgery.read more
Citations
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Immunosuppressive Drugs for Kidney Transplantation
TL;DR: This review considers the use of immunosuppressive drugs in organ transplantation, focusing on renal transplantation.
Journal ArticleDOI
Long-term renal allograft survival in the United States: a critical reappraisal.
TL;DR: The significant progress that has occurred over the last two decades in renal transplantation is mostly driven by improvements in short‐term graft survival but long‐term attrition is slowly improving and could lead to bigger advances in the future.
Journal ArticleDOI
A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study).
Flavio Vincenti,Bernard Charpentier,Yves Vanrenterghem,Lionel Rostaing,Barbara A. Bresnahan,P. Darji,Pablo U. Massari,G. A. Mondragón‐Ramirez,M. Agarwal,G. Di Russo,C.-S. Lin,P. Garg,Christian P. Larsen +12 more
TL;DR: Belatacept was associated with superior renal function and similar patient/graft survival versus cyclosporine at 1 year posttransplant, despite a higher rate of early acute rejection.
Journal ArticleDOI
Identifying Specific Causes of Kidney Allograft Loss
Ziad M. El-Zoghby,Mark D. Stegall,Donna J. Lager,Walter K. Kremers,Hatem Amer,James M. Gloor,Fernando G. Cosio +6 more
TL;DR: Targets for investigation and intervention are identified that may result in improved kidney transplantation outcomes and alloinmunity remains the most common mechanism leading to failure.
Journal ArticleDOI
Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data
TL;DR: Treating 100 recipients with tacrolimus instead of ciclosporin for the first year after transplantation avoids 12 patients having acute rejection and two losing their graft but causes an extra five patients to develop insulin dependent diabetes.
References
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Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Sundaram Hariharan,Christopher P. Johnson,Barbara A. Bresnahan,S. Taranto,Matthew McIntosh,Donald Stablein +5 more
TL;DR: There has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors since 1988.
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Risk factors for chronic rejection in renal allograft recipients.
P. S. Almond,A. J. Matas,K. J. Gillingham,David L. Dunn,William D. Payne,Paul F. Gores,Rainer W.G. Gruessner,J. S. Najarian +7 more
TL;DR: In this article, the authors found that acute rejection, CsA dosage < 5 mg/kg/day at 1 year, and infection are the major risk factors for the development of chronic rejection.
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