Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies.
Mehreen Zaigham,Ola Andersson +1 more
TLDR
The objective of this study was to summarize the clinical manifestations and maternal and perinatal outcomes of COVID‐19 during pregnancy.Abstract:
Introduction The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has exposed vulnerable populations to an unprecedented global health crisis. The knowledge gained from previous human coronavirus outbreaks suggests that pregnant women and their fetuses are particularly susceptible to poor outcomes. The objective of this study was to summarize the clinical manifestations and maternal and perinatal outcomes of COVID-19 during pregnancy. Material and methods We searched databases for all case reports and series from 12 February to 4 April 2020. Multiple terms and combinations were used including COVID-19, pregnancy, maternal mortality, maternal morbidity, complications, clinical manifestations, neonatal morbidity, intrauterine fetal death, neonatal mortality and SARS-CoV-2. Eligibility criteria included peer-reviewed publications written in English or Chinese and quantitative real-time polymerase chain reaction (PCR) or dual fluorescence PCR-confirmed SARS-CoV-2 infection. Unpublished reports, unspecified date and location of the study or suspicion of duplicate reporting, cases with suspected COVID-19 that were not confirmed by a laboratory test, and unreported maternal or perinatal outcomes were excluded. Data on clinical manifestations, maternal and perinatal outcomes including vertical transmission were extracted and analyzed. Results Eighteen articles reporting data from 108 pregnancies between 8 December 2019 and 1 April 2020 were included in the current study. Most reports described women presenting in the third trimester with fever (68%) and coughing (34%). Lymphocytopenia (59%) with elevated C-reactive protein (70%) was observed and 91% of the women were delivered by cesarean section. Three maternal intensive care unit admissions were noted but no maternal deaths. One neonatal death and one intrauterine death were also reported. Conclusions Although the majority of mothers were discharged without any major complications, severe maternal morbidity as a result of COVID-19 and perinatal deaths were reported. Vertical transmission of the COVID-19 could not be ruled out. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted.read more
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Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis.
John Allotey,Elena Stallings,Mercedes Bonet,Magnus Yap,Shaunak Chatterjee,Tania Kew,Luke Debenham,Anna Clavé Llavall,A. Dixit,D. Zhou,Rishab Balaji,Siang Ing Lee,X. Qiu,M. Yuan,Dyuti Coomar,Madelon van Wely,Elizabeth van Leeuwen,Elena Kostova,Heinke Kunst,Asma Khalil,Simon Tiberi,Vanessa Brizuela,Nathalie Broutet,Edna Kara,Caron Kim,Anna Thorson,Olufemi T Oladapo,Lynne M. Mofenson,Javier Zamora,Shakila Thangaratinam +29 more
TL;DR: Pregnant and recently pregnant women are less likely to manifest covid-19 related symptoms of fever and myalgia than non-pregnant women of reproductive age, and high intensive care women without high risk of disease are potentially more likely to be risk factors for covid19 Pre-existing comorbidity.
Dataset
Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA, March (online).
Lan Dong,Jinhua Tian,Songming He +2 more
TL;DR: In this article, resultados laboratoriais that mostram inflamacao and lesao hepatica indiretamente suportam a possibilidade de transmissão vertical.
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The impact of the COVID-19 pandemic on maternal and perinatal health: a scoping review.
TL;DR: In this paper, a scoping review was conducted to compile evidence on direct and indirect impacts of the COVID-19 pandemic on maternal health and provide an overview of the most significant outcomes thus far.
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The impact of the COVID-19 pandemic on women's mental health.
TL;DR: Women who are pregnant, postpartum, miscarrying, or experiencing intimate partner violence are at especially high risk for developing mental health problems during the pandemic, and proactive outreach to these groups of women and enhancement of social supports could lead to prevention, early detection, and prompt treatment.
Journal ArticleDOI
Clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnancies: a United States cohort study.
Rebecca Pierce-Williams,Julia Burd,Laura Felder,Rasha Khoury,Peter S. Bernstein,Karina Avila,Christina A. Penfield,Ashley S. Roman,Chelsea DeBolt,Joanne Stone,Angela Bianco,Adina R. Kern-Goldberger,Adi Hirshberg,Sindhu K. Srinivas,Jenani S. Jayakumaran,Justin S. Brandt,Hannah Anastasio,Meredith L. Birsner,Devon S. O’Brien,Harish M. Sedev,Cara D. Dolin,William T. Schnettler,Anju Suhag,Shabani Ahluwalia,Reshama Navathe,Adeeb Khalifeh,Kathryn Anderson,Vincenzo Berghella +27 more
TL;DR: The clinical course of severe and critical infection in hospitalized pregnant women with positive laboratory testing for SARS-CoV2 is described, followed by the median disease day on which these outcomes occurred after the onset of symptoms.
References
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Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.
Huijun Chen,Juanjuan Guo,Chen Wang,Fan Luo,Xuechen Yu,Wei Zhang,Jiafu Li,Dongchi Zhao,Dan Xu,Qing Gong,Jing Liao,Huixia Yang,Wei Hou,Yuanzhen Zhang +13 more
TL;DR: Wang et al. as mentioned in this paper evaluated the clinical characteristics of COVID-19 pneumonia in pregnant women and the intrauterine vertical transmission potential of CoV-19 infection in late pregnancy.
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Methodological quality and synthesis of case series and case reports.
TL;DR: A tool is proposed to evaluate the methodological quality of case reports and case series based on the domains of selection, ascertainment, causality and reporting and signalling questions to aid evidence-based practitioners and systematic reviewers in their assessment.