mTOR signaling at a glance
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TLDR
The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival.Abstract:
The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival. Discoveries that have been made over the last decade show that the mTOR pathway is activatedread more
Citations
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Journal ArticleDOI
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Yasemin Sancak,Liron Bar-Peled,Roberto Zoncu,Andrew L. Markhard,Shigeyuki Nada,David M. Sabatini +5 more
TL;DR: It is shown that amino acids induce the movement of m TORC1 to lysosomal membranes, where the Rag proteins reside, and Rag-Ragulator-mediated translocation of mTORC1 is the key event in amino acid signaling to mtorC1.
Journal ArticleDOI
The role of autophagy in neurodegenerative disease
TL;DR: An overview of the role of autophagy in neurodegenerative disease is provided, focusing particularly on less frequently considered lysosomal clearance mechanisms and their considerable impact on disease.
Journal ArticleDOI
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu,Seong A. Kang,Jonathan Rameseder,Yi Zhang,Kathleen Ottina,Kathleen Ottina,Daniel Lim,Timothy R. Peterson,Yongmun Choi,Nathanael S. Gray,Michael B. Yaffe,Jarrod A. Marto,David M. Sabatini +12 more
TL;DR: It is found that the phosphorylation response to insulin is largely mTOR dependent and that mTOR exhibits a unique preference for proline, hydrophobic, and aromatic residues at the +1 position.
Journal ArticleDOI
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Timothy R. Peterson,Shomit Sengupta,Thurl E. Harris,Anne E. Carmack,Seong A. Kang,Eric Balderas,David A. Guertin,Katherine L. Madden,Anne E. Carpenter,Brian N. Finck,David M. Sabatini +10 more
TL;DR: It is demonstrated that mTORC1 regulates SREBP by controlling the nuclear entry of lipin 1, a phosphatidic acid phosphatase, which is a key component of the m TORC1-SREBP pathway.
Journal ArticleDOI
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
Greg M. Delgoffe,Kristen N. Pollizzi,Adam T. Waickman,Emily Heikamp,David J. Meyers,Maureen R. Horton,Bo Xiao,Paul F. Worley,Jonathan D. Powell +8 more
TL;DR: It is demonstrated that differentiation into the TH1 and TH17 subsets of helper T cells was selectively regulated by signaling from mTOR complex 1 (mTORC1) that was dependent on the small GTPase Rheb.
References
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Journal ArticleDOI
AKT/PKB signaling: navigating downstream.
TL;DR: Those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration are discussed.
PatentDOI
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
TL;DR: In this paper, the rictor-mTOR complex was used to identify compounds which modulate Akt activity mediated by the Rictor mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activation.
Journal ArticleDOI
TSC2 mediates cellular energy response to control cell growth and survival.
TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.
Journal ArticleDOI
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M. Gwinn,David B. Shackelford,Daniel F. Egan,Maria M. Mihaylova,Annabelle Mery,Debbie S. Vasquez,Benjamin E. Turk,Reuben J. Shaw +7 more
TL;DR: AMPK directly phosphorylates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation induces 14-3-3 binding to raptor, uncovering a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status.
Journal ArticleDOI
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Do Hyung Kim,Dos D. Sarbassov,Siraj M. Ali,Jessie E. King,Robert R. Latek,Hediye Erdjument-Bromage,Paul Tempst,David M. Sabatini +7 more
TL;DR: It is reported that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two roles in the mTOR pathway that through its association with mTOR regulates cell size in response to nutrient levels.