Journal ArticleDOI
Myocardial Phosphocreatine-to-ATP Ratio Is a Predictor of Mortality in Patients With Dilated Cardiomyopathy
Stefan Neubauer,Michael Horn,Monika Cramer,Kerstin Harre,John B. Newell,Werner Peters,Thomas Pabst,Georg Ertl,Dietbert Hahn,Joanne S. Ingwall,Kurt Kochsiek +10 more
TLDR
The myocardial phosphocreatine-to-ATP ratio, measured noninvasively with 31P-MR spectroscopy, is a predictor of both total and cardiovascular mortality in patients with dilated cardiomyopathy.Abstract:
Background In patients with heart failure due to dilated cardiomyopathy, cardiac energy metabolism is impaired, as indicated by a reduction of the myocardial phosphocreatine-to-ATP ratio, measured noninvasively by 31P-MR spectroscopy. The purpose of this study was to test whether the phosphocreatine-to-ATP ratio also offers prognostic information in terms of mortality prediction as well as how this index compares with well-known mortality predictors such as left ventricular ejection fraction (LVEF) or New York Heart Association (NYHA) class. Methods and Results Thirty-nine patients with dilated cardiomyopathy were followed up for 928±85 days (2.5 years). At study entry, LVEF and NYHA class were determined, and the cardiac phosphocreatine-to-ATP ratio was measured by localized 31P-MR spectroscopy of the anterior myocardium. During the study period, total mortality was 26%. Patients were divided into two groups, one with a normal phosphocreatine-to-ATP ratio (>1.60; mean±SE, 1.98±0.07; n=19; healthy volunte...read more
Citations
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Journal ArticleDOI
The failing heart--an engine out of fuel.
TL;DR: This review describes cardiac energy metabolism, appraises the methods used for its assessment, evaluates the role of impaired energy metabolism in heart failure, and gives options for metabolic therapy.
Journal ArticleDOI
Myocardial Substrate Metabolism in the Normal and Failing Heart
TL;DR: This review discusses the metabolic changes that occur in chronic heart failure, with emphasis on the mechanisms that regulate the changes in the expression of metabolic genes and the function of metabolic pathways and the consequences of these metabolic changes on cardiac function.
Journal ArticleDOI
Left Ventricular Hypertrophy Pathogenesis, Detection, and Prognosis
TL;DR: This review will focus on the pathogenesis of pressure- versus volume-overload types of left ventricular hypertrophy (LVH), detection, and chronichypertrophy, which may be deleterious because it increases the risk for the development of heart failure and premature death.
Journal ArticleDOI
ACCF/ACR/AHA/NASCI/SCMR 2010 Expert Consensus Document on Cardiovascular Magnetic Resonance A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents
W. Gregory Hundley,David A. Bluemke,J. Paul Finn,Scott D. Flamm,Mark A. Fogel,Matthias G. Friedrich,Vincent B. Ho,Vincent B. Ho,Michael Jerosch-Herold,Christopher M. Kramer,Warren J. Manning,Manesh R. Patel,Gerald M. Pohost,Arthur E. Stillman,Richard D. White,Pamela K. Woodard +15 more
TL;DR: This dissertation aims to provide a history of FACC-FAHA education in the United States from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which FACC was introduced.
Journal ArticleDOI
Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report.
Dudley J. Pennell,Udo Sechtem,Charles B. Higgins,Warren J. Manning,Gerald M. Pohost,Frank Rademakers,Albert C. van Rossum,Leslee J. Shaw,E. Kent Yucel +8 more
TL;DR: The appropriateness of using CMR is described for the frequent disease entities where imaging information may be warranted, and the usefulness of CMR in specific diseases is summarized by means of the following classification.
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