Journal ArticleDOI
Nanozymes in bionanotechnology: from sensing to therapeutics and beyond
TLDR
The diverse applications of nanozymes, which range from sensing, imaging, and therapeutics, to logic gates, pollutant removal, water treatment, etc, are discussed, and the current challenges facing nanozyme research are addressed.Abstract:
In the past few decades, researchers have developed lots of artificial enzymes with various materials to mimic the structures and functions of natural enzymes. Recently, nanozymes, nanomaterials with enzyme-like characteristics, are emerging as novel artificial enzymes, and attracting researchers’ enormous interest. Remarkable advances have been made in the area of nanozymes due to their unique properties compared with natural enzymes and classic artificial enzymes. Until now, lots of nanomaterials have been studied to mimic various natural enzymes for wide applications. To highlight the recent progress of nanozymes (especially in bionanotechnology), here we discuss the diverse applications of nanozymes, which range from sensing, imaging, and therapeutics, to logic gates, pollutant removal, water treatment, etc. Finally, we address the current challenges facing nanozyme research as well as possible directions to fulfill their great potential in future.read more
Citations
More filters
Journal ArticleDOI
In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy.
Kelong Fan,Juqun Xi,Lei Fan,Peixia Wang,Chunhua Zhu,Yan Tang,Xiangdong Xu,Minmin Liang,Bing Jiang,Xiyun Yan,Lizeng Gao +10 more
TL;DR: It is shown that ferritin can direct nanoparticles to tumor cells and provide evidence that nitrogen-doped porous carbon nanospheres are powerful nanozymes capable of regulating intracellular reactive oxygen species, and ferritinylation is a promising strategy to render nanoZymes to target tumor cells for in vivo tumor catalytic therapy.
Journal ArticleDOI
Single-atom nanozymes
Liang Huang,Liang Huang,Jinxing Chen,Jinxing Chen,Linfeng Gan,Jin Wang,Shaojun Dong,Shaojun Dong +7 more
TL;DR: A new class of single-atom nanozymes with atomically dispersed enzyme-like active sites in nanomaterials is discovered, which significantly enhanced catalytic performance, and the underlying mechanism is uncovered.
Journal ArticleDOI
Molecular Imprinting on Inorganic Nanozymes for Hundred-fold Enzyme Specificity
TL;DR: Molecular imprinting furthers the functional enzyme mimicking aspect of nanozymes, and such hybrid materials will find applications in biosensor development, separation, environmental remediation, and drug delivery.
Journal ArticleDOI
Recent Advances in Nanozyme Research
Hui Wang,Kaiwei Wan,Xinghua Shi +2 more
TL;DR: The progress of experimental and computational research of nanoZymes on two issues over the past decade is briefly reviewed: experimental development of new nanozymes mimicking different types of enzymes and the catalytic mechanism proposed by experimental and theoretical study.
Journal ArticleDOI
Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors.
TL;DR: A biomimetic nanoflower based on self-assembly of nanozymes that can catalyze a cascade of intracellular biochemical reactions to produce ROS in both normoxic and hypoxic conditions without any external stimuli is developed.
References
More filters
Journal ArticleDOI
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Lizeng Gao,Jie Zhuang,Leng Nie,Jinbin Zhang,Yu Zhang,Ning Gu,Taihong Wang,Jing Feng,Dongling Yang,Sarah Perrett,Xiyun Yan +10 more
TL;DR: It is reported that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools.
Journal ArticleDOI
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Hui Wei,Erkang Wang +1 more
TL;DR: This review discusses various nanomaterials that have been explored to mimic different kinds of enzymes and covers their kinetics, mechanisms and applications in numerous fields, from biosensing and immunoassays, to stem cell growth and pollutant removal.
Journal ArticleDOI
Reactive Oxygen Species in Inflammation and Tissue Injury
TL;DR: The current review compiles the past and current research in the area of inflammation with particular emphasis on oxidative stress-mediated signaling mechanisms that are involved in inflammation and tissue injury.
Related Papers (5)
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Hui Wei,Erkang Wang +1 more