Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
TLDR
It is shown for the first time that Candida albicans, a eukaryotic pathogen, induces NET‐formation and is susceptible to NET‐mediated killing, and that granule components mediate fungal killing.Abstract:
Neutrophils phagocytose and kill microbes upon phagolysosomal fusion. Recently we found that activated neutrophils form extracellular fibres that consist of granule proteins and chromatin. These neutrophil extracellular traps (NETs) degrade virulence factors and kill Gram positive and negative bacteria. Here we show for the first time that Candida albicans, a eukaryotic pathogen, induces NET-formation and is susceptible to NET-mediated killing. C. albicans is the predominant aetiologic agent of fungal infections in humans, particularly in immunocompromised hosts. One major virulence trait of C. albicans is its ability to reversibly switch from singular budding cells to filamentous hyphae. We demonstrate that NETs kill both yeast-form and hyphal cells, and that granule components mediate fungal killing. Taken together our data indicate that neutrophils trap and kill ascomycetous yeasts by forming NETs.read more
Citations
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Contemporary Lifestyle and Neutrophil Extracellular Traps: An Emerging Link in Atherosclerosis Disease
TL;DR: Neutrophil extracellular traps (NETs) as discussed by the authors are a set of proteins of nuclear, granular and cytosolic origin that activated neutrophils expel under pathogenic inflammatory conditions, such as shear stress, lipidic molecules, pro-thrombotic factors, aggregated platelets, or pro-inflammatory cytokines.
Journal ArticleDOI
Tetrachlorobenzoquinone exhibits immunotoxicity by inducing neutrophil extracellular traps through a mechanism involving ROS-JNK-NOX2 positive feedback loop.
TL;DR: It is speculated that targeting NETs formation would be a promising therapeutic strategy in modulating the immunotoxicity of TCBQ.
Journal ArticleDOI
Deficient Neutrophil Extracellular Trap Formation in Patients Undergoing Bone Marrow Transplantation.
Jared W. Glenn,Mark J. Cody,Meghann Pine McManus,Michael A. Pulsipher,Joshua D. Schiffman,Christian C. Yost +5 more
TL;DR: In this article, the authors examined neutrophil extracellular traps (NE) formation in vitro in polymorphonuclear leukocyte (PMN) isolated from 24 patients who had undergone BMT for 13 different clinical indications.
Posted ContentDOI
Histone H3 clipping is a novel signature of human neutrophil extracellular traps
Tilley Do,Ulrike Abu-Abed,Arndt Uz,Markus Schmid,Florian S,Peter R. Jungblut,Brinkmann,Alf Herzig,Arturo Zychlinsky +8 more
TL;DR: In this article, a histone histone H3 cleavage event was identified and harnessed to develop a site-specific antibody for the detection of human extracellular traps (NETs).
Journal ArticleDOI
β-Nitrostyrene derivatives attenuate LPS-mediated acute lung injury via the inhibition of neutrophil-platelet interactions and NET release
Yao-Wen Chang,Ching-Ping Tseng,Chih Hsun Lee,Tsong-Long Hwang,Yu Li Chen,Mei Tzu Su,Kowit-Yu Chong,Kowit-Yu Chong,Ying Wei Lan,Chin Chung Wu,Kung Ju Chen,Fen Hua Lu,Hsiang Ruei Liao,Hsiang Ruei Liao,Chuen Hsueh,Chuen Hsueh,Pei Wen Hsieh +16 more
TL;DR: New insights are provided for elucidating the complicated regulation of neutrophils and platelets in ALI and sheds further light on future drug development strategies for ALI/ARDS and acute inflammatory diseases.
References
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Neutrophil extracellular traps kill bacteria
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