Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
TLDR
It is shown for the first time that Candida albicans, a eukaryotic pathogen, induces NET‐formation and is susceptible to NET‐mediated killing, and that granule components mediate fungal killing.Abstract:
Neutrophils phagocytose and kill microbes upon phagolysosomal fusion. Recently we found that activated neutrophils form extracellular fibres that consist of granule proteins and chromatin. These neutrophil extracellular traps (NETs) degrade virulence factors and kill Gram positive and negative bacteria. Here we show for the first time that Candida albicans, a eukaryotic pathogen, induces NET-formation and is susceptible to NET-mediated killing. C. albicans is the predominant aetiologic agent of fungal infections in humans, particularly in immunocompromised hosts. One major virulence trait of C. albicans is its ability to reversibly switch from singular budding cells to filamentous hyphae. We demonstrate that NETs kill both yeast-form and hyphal cells, and that granule components mediate fungal killing. Taken together our data indicate that neutrophils trap and kill ascomycetous yeasts by forming NETs.read more
Citations
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Neutrophil Extracellular Traps in Periodontitis: A Web of Intrigue.
TL;DR: The mechanisms, stimuli, and requirements for NET production; the ability of NET-DNA and NET-associated AMPs to entrap and kill pathogens; and the potential immunogenicity of NETs in disease are discussed.
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Crossroads of coagulation and innate immunity: the case of deep vein thrombosis.
TL;DR: An overview of DVT and the role of innate immune pathways supporting this process is given, closely linked to an evolutionary conserved immune defense mechanism activated in response to infections.
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The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases
Aldo Bonaventura,Luca Liberale,Luca Liberale,Federico Carbone,Alessandra Vecchié,Candela Diaz-Cañestro,Giovanni G. Camici,Fabrizio Montecucco,Franco Dallegri +8 more
TL;DR: The knowledge on neutrophil extracellular traps is updated, from their structure to their roles in infectious diseases as well as in cardiovascular diseases, autoimmunity, metabolic disorders and cancer, with a look to future perspectives and therapeutic opportunities.
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Inhibition of airway proteases in cystic fibrosis lung disease
TL;DR: The present review summarises and discusses the pathophysiological rationales, methodological requirements and clinical implications of inhibition of airway proteases in cystic fibrosis lung disease.
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Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis
Sandra Bonne-Année,Laura A. Kerepesi,Jessica A. Hess,Jordan Wesolowski,Fabienne Paumet,James B. Lok,Thomas J. Nolan,David Abraham +7 more
TL;DR: It is demonstrated that S. stercoralis larvae trigger the release of ETs by human neutrophils and macrophages, which ensnare the parasite facilitating larval killing by cells of the immune system.
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Neutrophil extracellular traps kill bacteria
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TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
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