Journal ArticleDOI
Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline.
D O Foster,M L Frydman +1 more
TLDR
Flow to heart and to muscles involved in respiratory movements was two to five times greater during calorigenesis and flow to most other tissues and organs increased or decreased by less than 40%.Abstract:
Cardiac output (CO) and the fractional distribution (FD) of γ-labeled plastic microspheres (15 ± 5 μm) injected into the left ventricle were used to calculate blood flow to organs and tissues of ba...read more
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Journal ArticleDOI
Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Journal ArticleDOI
Brown and beige fat: development, function and therapeutic potential
Matthew J. Harms,Patrick Seale +1 more
TL;DR: Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease.
Journal ArticleDOI
A role for brown adipose tissue in diet-induced thermogenesis
TL;DR: Measurement of energy balance during voluntary over-eating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance and suggests that this tissue may determine metabolic efficiency and resistance to obesity.
Journal ArticleDOI
Hypoxia and Adipose Tissue Function and Dysfunction in Obesity
TL;DR: Overall, hypoxia has pervasive effects on the function of adipocytes and appears to be a key factor in adipose tissue dysfunction in obesity.