Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function.
TLDR
Weight loss caused by various types of treatment, including low-calorie diet, intragastric balloon, and bariatric surgery, significantly improves lung function and metabolic syndrome and reduces body mass index.Abstract:
Obesity is currently one of the major epidemics of this millennium and affects individuals throughout the world. It causes multiple systemic complications, some of which result in severe impairment of organs and tissues. These complications involve mechanical changes caused by the accumulation of adipose tissue and the numerous cytokines produced by adipocytes. Obesity also significantly interferes with respiratory function by decreasing lung volume, particularly the expiratory reserve volume and functional residual capacity. Because of the ineffectiveness of the respiratory muscles, strength and resistance may be reduced. All these factors lead to inspiratory overload, which increases respiratory effort, oxygen consumption, and respiratory energy expenditure. It is noteworthy that patterns of body fat distribution significantly influence the function of the respiratory system, likely via the direct mechanical effect of fat accumulation in the chest and abdominal regions. Weight loss caused by various types of treatment, including low-calorie diet, intragastric balloon, and bariatric surgery, significantly improves lung function and metabolic syndrome and reduces body mass index. Despite advances in the knowledge of pulmonary and systemic complications associated with obesity, longitudinal randomized studies are needed to assess the impact of weight loss on metabolic syndrome and lung function.read more
Citations
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Impact of the driving pressure on mortality in obese and non-obese ARDS patients: a retrospective study of 362 cases.
Audrey De Jong,Jeanne Cossic,Daniel Verzilli,Clément Monet,Julie Carr,Mathieu Conseil,Marion Monnin,M. Cisse,Fouad Belafia,Nicolas Molinari,Gerald Chanques,Samir Jaber +11 more
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Association of obesity and its genetic predisposition with the risk of severe COVID-19: Analysis of population-based cohort data.
TL;DR: In this large population-based cohort, individuals with more-severe obesity, central obesity, or genetic predisposition for obesity are at higher risk of developing severe-COVID-19.
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Adult obesity complications: challenges and clinical impact.
TL;DR: Epidemiological data on the complications of adult obesity is presented and some of the challenges associated with managing this disease at a population and individual level are discussed.
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Association between underweight and pulmonary function in 282,135 healthy adults: A cross-sectional study in Korean population
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