Quantitative OCT angiography of optic nerve head blood flow
Yali Jia,John C. Morrison,Jason Tokayer,Ou Tan,Lorinna Lombardi,Bernhard Baumann,Chen D. Lu,WooJhon Choi,James G. Fujimoto,David Huang +9 more
TLDR
OCT angiography can detect the abnormalities of ONH perfusion and has the potential to reveal the ONH blood flow mechanism related to glaucoma, a pilot study indicates.Abstract:
Optic nerve head (ONH) blood flow may be associated with glaucoma development. A reliable method to quantify ONH blood flow could provide insight into the vascular component of glaucoma pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), we developed a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) for imaging ONH microcirculation. In this study, a method to quantify SSADA results was developed and used to detect ONH perfusion changes in early glaucoma. En face maximum projection was used to obtain 2D disc angiograms, from which the average decorrelation values (flow index) and the percentage area occupied by vessels (vessel density) were computed from the optic disc and a selected region within it. Preperimetric glaucoma patients had significant reductions of ONH perfusion compared to normals. This pilot study indicates OCT angiography can detect the abnormalities of ONH perfusion and has the potential to reveal the ONH blood flow mechanism related to glaucoma.read more
Citations
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Journal ArticleDOI
Optical coherence tomography angiography.
TL;DR: The integration of OCTA in multimodal imaging in the evaluation of retinal vascular occlusive diseases, diabetic retinopathy, uveitis, inherited diseases, age-related macular degeneration, and disorders of the optic nerve is presented.
Journal ArticleDOI
A review of optical coherence tomography angiography (OCTA).
TL;DR: OCTA is quick and non-invasive, and provides volumetric data with the clinical capability of specifically localizing and delineating pathology along with the ability to show both structural and blood flow information in tandem, its current limitations include a relatively small field of view.
Journal ArticleDOI
Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration
Yali Jia,Steven T. Bailey,David J. Wilson,Ou Tan,Michael L. Klein,Christina J. Flaxel,Benjamin Potsaid,Benjamin Potsaid,Jonathan J. Liu,Chen D. Lu,Martin F. Kraus,Martin F. Kraus,James G. Fujimoto,David Huang +13 more
TL;DR: Optical coherence tomography angiography provides depth-resolved information and detailed images of CNV in neovascular AMD and provides more distinct vascular network patterns that were less obscured by subretinal hemorrhage.
Journal ArticleDOI
Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications.
Amir H. Kashani,Chieh-Li Chen,Jin Kyu Gahm,Fang Zheng,Grace M. Richter,Philip J. Rosenfeld,Yonggang Shi,Ruikang K. Wang +7 more
TL;DR: The methods used to create OCTA images, the practical applications of OCTA in light of invasive dye‐imaging studies (e.g. fluorescein angiography) and clinical studies demonstrating the utility of OCT a for research and clinical practice are discussed.
Journal ArticleDOI
Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma
Yali Jia,Eric Wei,Xiaogang Wang,Xinbo Zhang,John C. Morrison,Mansi Parikh,Lori H. Lombardi,Devin M. Gattey,Rebecca L. Armour,Beth Edmunds,Martin F. Kraus,Martin F. Kraus,James G. Fujimoto,David Huang +13 more
TL;DR: Optical coherence tomography angiography, generated by the new SSADA, repeatably measures optic disc perfusion and may be useful in the evaluation of glaucoma and glAUcoma progression.
References
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Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Book ChapterDOI
Optical Coherence Tomography
Eric A. Swanson,J. Izatt,M. Bee,David Huang,Charles P. Lin,Carmen A. Puliafito,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease as mentioned in this paper, where OCT is an interferometric technique that detects reflected and backscattered light from tissue.
Journal ArticleDOI
Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
Yali Jia,Ou Tan,Jason Tokayer,Benjamin Potsaid,Y. Wang,Jonathan J. Liu,Martin F. Kraus,Hrebesh M. Subhash,James G. Fujimoto,Joachim Hornegger,David Huang +10 more
TL;DR: In this paper, a split-spectrum amplitude-decorrelation angiography (SSADA) was proposed to improve the signal-to-noise ratio (SNR) of flow detection.
Journal Article
Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
Yali Jia,Ou Tan,Jason Tokayer,Benjamin Potsaid,Y. Wang,Jonathan J. Liu,Martin F. Kraus,Hrebesh M. Subhash,James G. Fujimoto,Joachim Hornegger,David Huang +10 more
TL;DR: In this paper, a split-spectrum amplitude-decorrelation angiography (SSADA) was proposed to improve the signal-to-noise ratio (SNR) of flow detection.
Journal ArticleDOI
Speckle variance detection of microvasculature using swept-source optical coherence tomography
Adrian Mariampillai,Beau A. Standish,Eduardo H. Moriyama,Mamta Khurana,Nigel R. Munce,Michael K. K. Leung,James Jiang,Alex Cable,Brian C. Wilson,I. Alex Vitkin,Victor X. D. Yang +10 more
TL;DR: This technique can visualize vessel-size-dependent vascular shutdown and transient vascular occlusion during Visudyne photodynamic therapy and may provide opportunities for studying therapeutic effects of antivascular treatments without on exogenous contrast agent.