Reversal of the Symptoms of Diabetic Neuropathy through Correction of Vitamin D Deficiency in a Type 1 Diabetic Patient
TLDR
A type 1 diabetic patient with neuropathic symptoms so severe that he could not work and for which he needed narcotics for pain management and whose symptoms improved dramatically with correction of the vitamin D deficiency is described.Abstract:
Vitamin D deficiency has been associated with both type 1 and type 2 diabetes as well as both the microvascular and macrovascular complications of diabetes. Vitamin D deficiency has been shown to be more common in diabetic patients who have symptoms of distal symmetrical polyneuropathy. In addition, vitamin D deficiency has been associated with a lower pain threshold which increases when vitamin D deficiency is corrected. Herein, I describe a type 1 diabetic patient with neuropathic symptoms so severe that he could not work and for which he needed narcotics for pain management and whose symptoms improved dramatically with correction of the vitamin D deficiency. To my knowledge, this is the first report of an improvement in severe symptoms of diabetic neuropathy with correction of vitamin D deficiency in a single patient.read more
Citations
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Journal ArticleDOI
Vitamin D for the treatment of painful diabetic neuropathy
Abdul Basit,Khalid Abdul Basit,Asher Fawwad,Fariha Shaheen,Nimra Fatima,Ioannis N. Petropoulos,Uazman Alam,Rayaz A. Malik,Rayaz A. Malik +8 more
TL;DR: Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic Neuropathy.
Journal ArticleDOI
Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus.
TL;DR: Serum 25(OH)D concentrations significantly improved after oral vitamin D supplementation in the treatment group when compared to the placebo group, and no improvement was observed for NDS and NCS between the 2 groups after treatment.
Journal ArticleDOI
Vitamin D and diabetes mellitus: Causal or casual association?
TL;DR: Up to date evidence linking vitamin D with the development of diabetes and the role of vitamin D supplementation in the prevention of both types of diabetes is analysed together with its role in improving glycemic control in diabetic patients.
Journal ArticleDOI
The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus
Celil Alper Usluogullari,Fevzi Balkan,Sedat Caner,Rifki Ucler,Cafer Kaya,Reyhan Ersoy,Bekir Cakir +6 more
TL;DR: Serum 25-OH vitamin D levels were lower in diabetic patients with nephropathy, and patients not using any medication, i.e., those treated with dietary changes alone, had a higher prevalence of nephtropathy.
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The association between vitamin D level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: An update systematic review and meta-analysis.
TL;DR: Vitamin D deficiency is associated with the generation and development of DPN in Caucasian with T2DM, and in Asian, diabetic patients with vitamin D deficiency are 1.22 times to suffer from DPN compared with normal vitamin D level.
References
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A Systematic Review and Meta-analysis
TL;DR: A systematic review of studies published from January 1, 1950, through November 31, 2008 using PubMed, EMBASE, Web of Knowledge, CINAHL, and all Evidence-Based Medicine Reviews found that randomized clinical trials and prospective studies of RRTs that reported data on changes in the primary outcome of hospital mortality or the secondary outcome of cardiopulmonary arrest cases were included.
Journal ArticleDOI
The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis
TL;DR: Evidence from trials with vitamin D and/or calcium supplementation suggests that combined Vitamin D and calcium supplementation may have a role in the prevention of type 2 DM only in populations at high risk (i.e. glucose intolerance).
Journal ArticleDOI
Prevalence of Severe Hypovitaminosis D in Patients With Persistent, Nonspecific Musculoskeletal Pain
TL;DR: All patients with persistent, nonspecific musculoskeletal pain are at high risk for the consequences of unrecognized and untreated severe hypovitaminosis D.
Journal ArticleDOI
Diabetic peripheral neuropathic pain: clinical and quality-of-life issues.
TL;DR: The current knowledge about and recommendations for diagnostic assessment of DPN pain are reviewed and presented based on a review of the literature.
Journal ArticleDOI
Vitamin D as an Analgesic for Patients With Type 2 Diabetes and Neuropathic Pain
Paul H. Lee,Roger Chen +1 more
TL;DR: The objective was to evaluate the impact of vitamin D repletion on neuropathic pain in patients with type 2 diabetes and vitamin D insufficiency.
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