Journal ArticleDOI
Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung
David W. Cushman,H.S. Cheung +1 more
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A sensitive, fixed-time, spectrophotometric assay for angiotensin-converting enzyme measures the rate of production of hippuric acid from hippuryl-L -histidyl- L -leucine (HHL).About:
This article is published in Biochemical Pharmacology.The article was published on 1971-07-01. It has received 2493 citations till now. The article focuses on the topics: Enzyme assay & Angiotensin II.read more
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Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents
TL;DR: A hypothetical model of the active site of angiotensin-converting enzyme, based on known chemical and kinetic properties of the enzyme, has enabled a new class of potent and specific inhibitors, carboxyalkanoyl and mercaptoalkanoysl derivatives of proline, to be designed.
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Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids.
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Elevation of serum angiotension-converting-enzyme (ACE) level in sarcoidosis
TL;DR: The level of serum angiotensin-converting enzyme (ACE) was elevated in 15 of 17 patients with active sarcoidosis as mentioned in this paper, whereas levels in patients with sarcolidosis not receiving steroids were greater than 2 standard deviations above the mean for the adult control subjects.
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Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk
TL;DR: The inhibitory activity of angiotensin I-converting enzyme in milk increased during fermentation with the Calpis sour milk starter containing Lactobacillus helveticus and Saccharomyces cerevisiae.
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
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A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.
TL;DR: The spectrophotometric procedure proposed by Schwert and Takenaka has been modified and extended to include the application to N-benzoyl-L-tyrosine ethyl ester and α-p-toluenesulphonyl- L-arginine methyl ester, allowing the determination of traces of chymotrypsin in the presence of relatively large amounts of trypsin.
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The preparation and function of the hypertensin-converting enzyme.
TL;DR: It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensIn I is not, and it would appear that in intact animals the pressor activity of hypertens in I results from its rapid conversion to hypertENSin II.
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Conversion of angiotensin I to angiotensin II.
K. K. F. Ng,John R. Vane +1 more
TL;DR: Results obtained with the blood bathed organ technique indicate that angiotensin I is converted rapidly to angiotENSin II in the pulmonary circulation and not by an enzyme in the blood.