Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period
Maria-Angeliki Gkini,Alexandros-Efstratios Kouskoukis,Gregory Tripsianis,Dimitris Rigopoulos,Konstantinos Kouskoukis +4 more
TLDR
The data suggest that PRP injections may have a positive therapeutic effect on male and female pattern hair loss without remarkable major side effects.Abstract:
Background: Platelet-rich plasma (PRP) is defined as an autologous concentration of plasma with a greater count of platelets than that of whole blood. Its action depends on the released growth factors from platelets. It has been investigated and used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss. Aims: To evaluate the efficacy and safety of PRP injections in the scalp of patients with androgenetic alopecia. Settings and Design: Prospective cohort study. Materials and Methods: 20 patients, 18 males and 2 females, with androgenetic alopecia were enrolled in the study. PRP was prepared using a single spin method (Regenlab SA). Upon activation, it was injected in the androgen-related areas of scalp. Three treatment sessions were performed with an interval of 21 days and a booster session at 6 months following the onset of therapy. Statistical Analysis: Statistical analysis of the data was performed using the Statistical Package for the Social Sciences (SPSS), version 19.0 (IBM, NY, USA). Results: Hair loss reduced and at 3 months it reached normal levels. Hair density reached a peak at 3 months (170.70 ± 37.81, P < 0.001). At 6 months and at 1 year, it was significantly increased, 156.25 ± 37.75 (P < 0.001) and 153.70 ± 39.92 (P < 0.001) respectively, comparing to baseline. Patients were satisfied with a mean result rating of 7.1 on a scale of 1-10. No remarkable adverse effects were noted. Conclusions: Our data suggest that PRP injections may have a positive therapeutic effect on male and female pattern hair loss without remarkable major side effects. Further studies are needed to confirm its efficacy.read more
Citations
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The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial
Pietro Gentile,Pietro Gentile,Simone Garcovich,Alessandra Bielli,Maria Giovanna Scioli,Augusto Orlandi,Valerio Cervelli +6 more
TL;DR: The data clearly highlight the positive effects of PRP injections on male pattern hair loss and absence of major side effects, and PRP may serve as a safe and effective treatment option against hair loss.
Journal ArticleDOI
Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men - short version.
Varvara Kanti,Andrew G. Messenger,G. Dobos,Pascal Reygagne,A. Finner,Anja Blumeyer,Myrto Trakatelli,Antonella Tosti,V. Del Marmol,Bianca Maria Piraccini,Alexander Nast,Ulrike Blume-Peytavi +11 more
TL;DR: The purpose of the guideline is to provide dermatologists with an evidence‐based tool for choosing an efficacious and safe therapy for patients with androgenetic alopecia.
Journal ArticleDOI
Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia.
Rubina Alves,Ramon Grimalt +1 more
TL;DR: Application of PRP showed a positive effect on AGA and could be regarded as an adjuvant therapy for AGA and a correlation between anagen hairs and patients >40 years and beginning of AGA was found.
Journal ArticleDOI
Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development.
Pietro Gentile,Simone Garcovich +1 more
TL;DR: The significant improvements in intraoperative stem cell approaches, from in vivo models to clinical investigations, are reviewed and the potential regenerative instruments and functions of various cell populaces in the hair regrowth process are discussed.
Journal ArticleDOI
Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems.
Pietro Gentile,Pietro Gentile,John P Cole,Megan A. Cole,Simone Garcovich,Alessandra Bielli,Maria Giovanna Scioli,Augusto Orlandi,Chiara Insalaco,Valerio Cervelli +9 more
TL;DR: Platelet rich plasma (PRP) was tested as a potential therapy for androgenetic alopecia through two different clinical protocols in which one population received half-head treatment with autologous non-activated PRP produced by CPunT Preparation System and the other half- head with placebo.
References
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Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma: Implications for Wound Healing
TL;DR: A variety of potentially therapeutic growth factors were detected and released from the platelets in significant levels in platelet-rich plasma preparations and may be capable of expediting wound healing in a variety of as yet undetermined specific wound applications.
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Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count
TL;DR: There was substantial variation in the growth factor content of platelet-rich plasma, and the factors influencing this are still worthy of further investigation.
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Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth
Zheng Jun Li,Hye-In Choi,Dae-Kyoung Choi,Kyung-Cheol Sohn,Myung Im,Young-Joon Seo,Young-Ho Lee,Jeung-Hoon Lee,Young Ho Lee +8 more
TL;DR: Support is provided for possible clinical application of autologous PRP and its secretory factors for promotion of hair growth using in vivo and in vitro models.
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Psychological effects of androgenetic alopecia on women: Comparisons with balding men and with female control subjects*
TL;DR: The results confirm the psychologically detrimental effects of androgenetic alopecia, especially on women, and the implications for patient care are discussed.
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The role of platelet plasma growth factors in male pattern baldness surgery.
TL;DR: An improvement that can be introduced into baldness surgery clinics with less morbidity and a low cost-to-benefit ratio is demonstrated, and further studies may improve the efficiency of the technique and allow digital programs to better evaluate the increase in hair density.