Journal ArticleDOI
The hazard of accelerated tumor clonogen repopulation during radiotherapy.
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TLDR
It is suggested that, on average, clonogen repopulation in squamous cell carcinomas of the head and neck accelerates only after a lag period of the order of 4 +/- 1 weeks after initiation of radiotherapy and that a dose increment of about 0.6 Gy per day is required to compensate for this repopulating.Abstract:
When analysis of results of radiotherapy for nearly 500 patients with oropharyngeal cancer showed evidence for rapid tumor regrowth during extensions of treatment from about 5 weeks to about 8 week...read more
Citations
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The linear-quadratic formula and progress in fractionated radiotherapy
TL;DR: Clinical gains have been reported from the use of nonstandard fractionation schedules planned with a radiobiological basis, with Hyperfractionation providing the leading example, as described below.
Journal ArticleDOI
Clinical practice guidelines in oncology
William J. Gradishar,Benjamin O. Anderson,Ron Balassanian,Sarah L. Blair,Harold J. Burstein,Amy E. Cyr,Anthony D. Elias,William B. Farrar,Andres Forero,Sharon H. Giordano,Matthew P. Goetz,Lori J. Goldstein,Steven J. Isakoff,Janice A. Lyons,P. Kelly Marcom,Ingrid A. Mayer,Beryl McCormick,Meena S. Moran,Ruth O'Regan,Sameer A. Patel,Lori J. Pierce,Elizabeth C. Reed,Kilian E. Salerno,Lee S. Schwartzberg,Amy Sitapati,Karen L. Smith,Mary Lou Smith,Hatem Soliman,George Somlo,Melinda L. Telli,John H. Ward,Rashmi Kumar,Dorothy A. Shead +32 more
TL;DR: This manuscript focuses on the NCCN Guidelines Panel recommendations for the workup, primary treatment, risk reduction strategies, and surveillance specific to DCIS.
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Hyperfractionated Irradiation with or without Concurrent Chemotherapy for Locally Advanced Head and Neck Cancer
David M. Brizel,Mary E. Albers,Samuel R. Fisher,Richard L. Scher,William J. Richtsmeier,Vera Hars,Stephen L. George,Andrew T. Huang,Leonard R. Prosnitz +8 more
TL;DR: Combined treatment for advanced head and neck cancer is more efficacious and not more toxic than hyperfractionated irradiation alone.
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Strategies to improve radiotherapy with targeted drugs
TL;DR: Improved understanding of the molecular response of cells and tissues to ionizing radiation and a new appreciation of the exploitable genetic alterations in tumours have led to the development of treatments combining pharmacological interventions with ionizing Radiation that more specifically target either tumour or normal tissue, leading to improvements in efficacy.
Journal ArticleDOI
Repopulation of cancer cells during therapy: an important cause of treatment failure
John Kim,Ian F. Tannock +1 more
TL;DR: New strategies to inhibit repopulation are emerging in parallel with advances in the understanding of underlying biological mechanisms in radiotherapy and chemotherapy.
References
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Book
analysis of binary data
David Cox,E. J. Snell +1 more
TL;DR: Binary response variables special logistical analyses some complications some related approaches more complex responses.
Journal ArticleDOI
A simplification in the use of the NSD concept in practical radiotherapy
C. G. Orton,F. Ellis +1 more
TL;DR: The purpose of this paper is to introduce a set of tables which are simple to use and general in application, and which help to ensure correct interpretation of the basic NSD concepts.
Journal ArticleDOI
Accelerated fractionation vs hyperfractionation: Rationales for several treatments per day
TL;DR: The choice between accelerated fractionation and hyperfractionation is determined by the regenerative capability of tumor clonogens during treatment, and a method of selection based on potential doubling times is presented.
Journal ArticleDOI
Biologic basis for altered fractionation schemes
TL;DR: Fractionation spares slowly responding tissues more than tissues and tumors that show an early response, suggesting that therapeutic gains may be further increased by reducing fractional doses below 1.8 to 2 Gy.