The pathophysiology of endometriosis and adenomyosis: tissue injury and repair
TLDR
A physiological model is proposed that provides a comprehensive explanation of the local production of estrogen at the level of ectopic endometrial lesions and the endometrium of women affected with the disease, involving local estrogen production in an estrogen-sensitive environment normally controlled by the ovary.Abstract:
Introduction
This study presents a unifying concept of the pathophysiology of endometriosis and adenomyosis. In particular, a physiological model is proposed that provides a comprehensive explanation of the local production of estrogen at the level of ectopic endometrial lesions and the endometrium of women affected with the disease.read more
Citations
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Journal ArticleDOI
Endometriosis and infertility: pathophysiology and management.
TL;DR: Weighing up the relative advantages of surgery, medical treatment and ART are the foundations for a global approach to infertility associated with endometriosis.
Journal ArticleDOI
What we know about primary dysmenorrhea today: a critical review
TL;DR: The extensive multi-factorial impact of dysmenorrhea is demonstrated, evident even in phases of the menstrual cycle when women are not experiencing menstrual pain, illustrating that long-term differences in pain perception extend outside of the painful menstruation phase.
Journal ArticleDOI
Endometrial stem/progenitor cells: the first 10 years
TL;DR: The discovery of specific markers for endometrial stem/progenitor cells has enabled the examination of their role in endometrian proliferative disorders, including endometriosis, adenomyosis and Asherman's syndrome.
Journal ArticleDOI
Adult Stem Cells in the Endometrium
TL;DR: An overview of the accumulating evidence for endometrial stem/progenitor cells and their possible roles inendometrial proliferative disorders is provided, and emerging evidence suggests a bone marrow contribution.
References
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Journal ArticleDOI
Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity
Journal Article
Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation
Journal ArticleDOI
Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis
Richard O. Burney,Said Talbi,A.E. Hamilton,Kim Chi Vo,Mette Nyegaard,Camran Nezhat,Bruce A. Lessey,Linda C. Giudice +7 more
TL;DR: Global gene expression analysis of endometrium from women with and without moderate/severe stage endometriosis and compared the gene expression signatures across various phases of the menstrual cycle provided a framework for further investigations on causality and mechanisms underlying attenuated progesterone response inendometrium of women with endometRIosis.
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Aromatase expression in endometriosis.
TL;DR: The presence of aromatase expression in eutopic endometrial tissues from patients with endometriosis may be related to the capability of implantation of these tissues on peritoneal surfaces and the possibility of estrogen production in these implants may serve to promote their growth.
Journal ArticleDOI
Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells.
Luis S. Noble,Kazuto Takayama,Khaled M. Zeitoun,J. Michael Putman,D. Alan Johns,Margaret M. Hinshelwood,Veena R. Agarwal,Ying Zhao,Bruce R. Carr,Serdar E. Bulun +9 more
TL;DR: The presence of P450arom mRNA is demonstrated in pelvic endometriotic implants and eutopic endometrial curettings of women withendometriosis and the hormonal regulation of aromatase expression and alternative promoter use in these cells is investigated.