The role of olfaction in host-seeking of mosquitoes: a review.

TLDR: Air-borne chemical cues that blood-seeking mosquitoes use to locate a host are concentrated on, finding that lactic acid in the presence of CO2 is attractive, and other host-produced chemicals are also attractive, but chemical identification and subsequent confirmation of attractiveness for mosquitoes has not been reported.

Abstract: This review concentrates on air-borne chemical cues that blood-seeking mosquitoes use to locate a host. A distinction is made between short- and long-range attraction. Carbon dioxide is involved in both processes. It activates and attracts mosquitoes. The latter function is only observed in combination with an odorous organo-chemical. Other olfactory cues are primarily involved in long-range attraction. Bodily emanations from the host that contain olfactory cues can be divided into three groups: Skin emanations, exhaled air and urine. Each of these is attractive to mosquitoes, but there is little knowledge about the chemical compounds that cause the attraction. Lactic acid in the presence of CO2 is attractive, and lactic acid-sensitive neurosensilla are present on the antennae. Other host-produced chemicals are also attractive, but chemical identification and subsequent confirmation of attractiveness for mosquitoes has not been reported. Host preference in mosquitoes is speciesspecific and varies from highly specific to opportunistic. Attraction is likely to be caused by a mixture of several compounds. Synergism may be an important way of increasing the effect of separate chemical cues.