Journal ArticleDOI
Toxicity of Gold Nanoparticles Functionalized with Cationic and Anionic Side Chains
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TLDR
Concentration-dependent lysis mediated by initial electrostatic binding was observed in dye release studies using lipid vesicles, providing the probable mechanism for observed toxicity with the cationic MMPCs.About:
This article is published in Bioconjugate Chemistry.The article was published on 2004-06-05. It has received 1471 citations till now. The article focuses on the topics: Cationic polymerization & Colloidal gold.read more
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Journal ArticleDOI
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Posted Content
Nanomaterials and nanoparticles: Sources and toxicity
TL;DR: A review of the toxicity of nanoparticles is presented in this paper, with the goal of informing public health concerns related to nanoscience while raising awareness of nanomaterials toxicity among scientists and manufacturers handling them.
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Nanomaterials and nanoparticles: Sources and toxicity
TL;DR: This review reveals the result of life’s long history of evolution in the presence of nanoparticles, and how the human body has adapted to defend itself against nanoparticulate intruders, while raising awareness of nanomaterials’ toxicity among scientists and manufacturers handling them.
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Nanomaterials in the environment: Behavior, fate, bioavailability, and effects
Stephen J. Klaine,Pedro J. J. Alvarez,Graeme E. Batley,Teresa F. Fernandes,Richard D. Handy,Delina Y. Lyon,Shaily Mahendra,Mike J. McLaughlin,Jamie R. Lead +8 more
TL;DR: This review critiques existing nanomaterial research in freshwater, marine, and soil environments and illustrates the paucity of existing research and demonstrates the need for additional research.
References
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Nucleic-acid therapeutics: basic principles and recent applications.
TL;DR: Different strategies for modulating gene expression are reviewed, and the successes and problems that are associated with this type of therapy are discussed.
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Quantitative and Reversible Lectin-Induced Association of Gold Nanoparticles Modified with α-Lactosyl-ω-mercapto-poly(ethylene glycol)
TL;DR: Lac-conjugated gold nanoparticles exhibited selective aggregation when exposed to Recinus communis agglutinin (RCA120), a bivalent lectin specifically recognizing the β-d-galactose residue, inducing significant changes in the absorption spectrum with concomitant visible color change from pinkish-red to purple.
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Gold nanoparticle-mediated transfection of mammalian cells.
TL;DR: Mixed monolayer protected gold clusters functionalized with quaternary ammonium chains efficiently transfect mammalian cell cultures, as determined through beta-galactosidase transfer and activity.
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Mimicry of host-defense peptides by unnatural oligomers: antimicrobial beta-peptides.
TL;DR: Some of the factors important for activity in this class of β-peptides are examined, including an amphiphilic helix is necessary, because a nonamphiphilic isomer proved to be inactive.
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Designing peptide receptor agonists and antagonists
TL;DR: A robust strategy has been developed for the design of peptides as drugs, drug candidates and biological tools that includes structural, conformational, dynamic and topographical considerations.