Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature.
TLDR
This review article proposes an algorithm of risk stratification and prevention of TLS in patients with solid cancers and summarizes the current data on the occurrence of cipher lysis syndrome in Patients with solid tumors.Abstract:
Tumor lysis syndrome (TLS) is a potentially deadly complication of tumors or their treatment. This syndrome consists of a constellation of laboratory findings such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, known as laboratory TLS. When clinical complications such as seizures, acute renal failure, and cardiac dysrhythmias occur in patients with laboratory TLS, the syndrome is called clinical TLS. TLS is especially common in patients with hematological malignancies with rapid cellular turnover rates such as acute lymphocytic leukemia and Burkitt lymphoma, but is very rare in patients with solid tumors. Nevertheless, there are multiple reports in the literature on the occurrence of TLS in patients with solid tumors. In this review article, we summarize the current data on the occurrence of TLS in patients with solid tumors. We propose an algorithm of risk stratification and prevention of TLS in patients with solid cancers.read more
Citations
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Ionic immune suppression within the tumour microenvironment limits T cell effector function
Robert L. Eil,Suman K. Vodnala,David Clever,Christopher A. Klebanoff,Christopher A. Klebanoff,Madhusudhanan Sukumar,Jenny H. Pan,Douglas C. Palmer,Alena Gros,Tori N. Yamamoto,Shashank J. Patel,Geoffrey Guittard,Zhiya Yu,Valentina Carbonaro,Klaus Okkenhaug,David S. Schrump,W. Marston Linehan,Rahul Roychoudhuri,Nicholas P. Restifo +18 more
TL;DR: An ionic checkpoint that blocks T cell function in tumours is uncovered and potential new strategies for cancer immunotherapy are identified, including boosting potassium efflux in tumour-specific T cells by overexpressing the potassium channel Kv1.3.
Journal ArticleDOI
Tumor lysis syndrome: A clinical review
TL;DR: Clinicians should stratify every hospitalized cancer patient and especially those receiving chemotherapy for the risk of tumor lysis syndrome, and several aspects of prevention include adequate hydration, use of uric acid lowering therapies,Use of phosphate binders and minimization of potassium intake.
Journal ArticleDOI
Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations
Kristen Renee McSweeney,Laura Kate Gadanec,Tawar Qaradakhi,Benazir Ashiana Ali,Anthony Zulli,Vasso Apostolopoulos +5 more
TL;DR: In this article, the authors detail the extensively known pathophysiology of cisplatin-induced nephrotoxicity that manifests and the variety of pharmacological and genetic alteration studies that target them.
Journal ArticleDOI
Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase.
TL;DR: Treatment of TLS consists of intensive hydration, stimulation of diuresis, and, more specifically, in the use of allopurinol and rasburicase, which rapidly and effectively reduces hyperuricemia, which subsequently significantly decreases the risk of acute renal failure and other clinical manifestations of TLS.
Journal ArticleDOI
Tumor Lysis Syndrome in Patients with Hematological Malignancies.
TL;DR: In this review a comprehensive search of literatures was performed using MEDLINE/PubMed, Hinari, the Cochrane library, and Google Scholar to summarize diagnostic criteria, incidence, predicting factors, prevention, and treatment options for tumor lysis syndrome in patients with hematological malignancies.
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