Virus Entry by Endocytosis
TLDR
This review focuses on the cell biology of virus entry and the different strategies and endocytic mechanisms used by animal viruses.Abstract:
Although viruses are simple in structure and composition, their interactions with host cells are complex. Merely to gain entry, animal viruses make use of a repertoire of cellular processes that involve hundreds of cellular proteins. Although some viruses have the capacity to penetrate into the cytosol directly through the plasma membrane, most depend on endocytic uptake, vesicular transport through the cytoplasm, and delivery to endosomes and other intracellular organelles. The internalization may involve clathrin-mediated endocytosis (CME), macropinocytosis, caveolar/lipid raft-mediated endocytosis, or a variety of other still poorly characterized mechanisms. This review focuses on the cell biology of virus entry and the different strategies and endocytic mechanisms used by animal viruses.read more
Citations
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Journal ArticleDOI
Mechanisms of clathrin-mediated endocytosis.
Marko Kaksonen,Aurélien Roux +1 more
TL;DR: Studies in recent years have provided several important insights into how endocytic vesicles are built, starting from initiation, cargo loading and the mechanisms governing membrane bending to membrane scission and the release of the vesicle into the cytoplasm.
Journal ArticleDOI
Physical Principles of Nanoparticle Cellular Endocytosis.
Sulin Zhang,Huajian Gao,Gang Bao +2 more
TL;DR: How the kinetics, energetics, and forces are related to these interactions and dependent on the size, shape, and stiffness of nanoparticles, the biomechanical properties of the cell membrane, as well as the local environment of the cells are discussed.
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Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)
Journal ArticleDOI
Subversion of the actin cytoskeleton during viral infection
TL;DR: How the interaction of viral proteins with the cell modulates the structure and function of the actin cytoskeleton to initiate, sustain and spread infections is described.
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Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.
Sara Sigismund,Stefano Confalonieri,Andrea Ciliberto,Simona Polo,Giorgio Scita,Pier Paolo Di Fiore +5 more
TL;DR: By combining the analysis of biochemical, biological, and evolutionary evidence, it is proposed that endocytosis constitutes one of the major enabling conditions that in the history of life permitted the development of a higher level of organization, leading to the actuation of the eukaryotic cell plan.
References
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