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Abhay P. Sagare
Researcher at University of Southern California
Publications - 97
Citations - 18024
Abhay P. Sagare is an academic researcher from University of Southern California. The author has contributed to research in topics: Blood–brain barrier & Medicine. The author has an hindex of 46, co-authored 81 publications receiving 13958 citations. Previous affiliations of Abhay P. Sagare include University of Rochester Medical Center & University of Rochester.
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Journal ArticleDOI
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
TL;DR: This Review discusses neuroimaging studies in the living human brain and post-mortem tissue as well as biomarker studies demonstrating BBB breakdown in Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-1-associated dementia and chronic traumatic encephalopathy.
Journal ArticleDOI
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
Axel Montagne,Samuel Barnes,Melanie D. Sweeney,Matthew R. Halliday,Abhay P. Sagare,Zhen Zhen Zhao,Arthur W. Toga,Russell E. Jacobs,Collin Y. Liu,Lilyana Amezcua,Michael G. Harrington,Helena C. Chui,Meng Law,Berislav V. Zlokovic +13 more
TL;DR: The data suggest that BBB breakdown is an early event in the aging human brain that begins in the hippocampus and may contribute to cognitive impairment.
Journal ArticleDOI
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.
Robert D. Bell,Ethan A. Winkler,Abhay P. Sagare,Itender Singh,Barb LaRue,Rashid Deane,Berislav V. Zlokovic +6 more
TL;DR: It is shown that age-dependent vascular damage in pericyte-deficient mice precedes neuronal degenerative changes, learning and memory impairment, and the neuroinflammatory response, and pericytes control key neurovascular functions that are necessary for proper neuronal structure and function.
Journal ArticleDOI
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
Robert D. Bell,Ethan A. Winkler,Itender Singh,Abhay P. Sagare,Rashid Deane,Zhenhua Wu,David M. Holtzman,Christer Betsholtz,Annika Armulik,Annika Armulik,Jan Sallstrom,Bradford C. Berk,Berislav V. Zlokovic,Berislav V. Zlokovic +13 more
TL;DR: It is shown that the vascular defects in Apoe-deficient and APOE4-expressing mice precede neuronal dysfunction and can initiate neurodegenerative changes, which suggest that CypA is a key target for treating APoe4-mediated neurovascular injury and the resulting neuronal Dysfunction and degeneration.
Journal ArticleDOI
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.
Daniel A. Nation,Melanie D. Sweeney,Axel Montagne,Abhay P. Sagare,Lina M. D'Orazio,Maricarmen Pachicano,Farshid Sepehrband,Amy R. Nelson,David P. Buennagel,Michael G. Harrington,Tammie L.S. Benzinger,Anne M. Fagan,John M. Ringman,Lon S. Schneider,John C. Morris,Helena C. Chui,Meng Law,Arthur W. Toga,Berislav V. Zlokovic +18 more
TL;DR: Neuroimaging and cerebrospinal fluid analyses in humans reveal that loss of blood–brain barrier integrity and brain capillary pericyte damage are early biomarkers of cognitive impairment that occur independently of changes in amyloid-β and tau.