M
Melanie D. Sweeney
Researcher at University of Southern California
Publications - 31
Citations - 8845
Melanie D. Sweeney is an academic researcher from University of Southern California. The author has contributed to research in topics: Blood–brain barrier & Dementia. The author has an hindex of 19, co-authored 29 publications receiving 5243 citations. Previous affiliations of Melanie D. Sweeney include Wistar Institute & Baylor College of Medicine.
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Journal ArticleDOI
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
TL;DR: This Review discusses neuroimaging studies in the living human brain and post-mortem tissue as well as biomarker studies demonstrating BBB breakdown in Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-1-associated dementia and chronic traumatic encephalopathy.
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Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
Axel Montagne,Samuel Barnes,Melanie D. Sweeney,Matthew R. Halliday,Abhay P. Sagare,Zhen Zhen Zhao,Arthur W. Toga,Russell E. Jacobs,Collin Y. Liu,Lilyana Amezcua,Michael G. Harrington,Helena C. Chui,Meng Law,Berislav V. Zlokovic +13 more
TL;DR: The data suggest that BBB breakdown is an early event in the aging human brain that begins in the hippocampus and may contribute to cognitive impairment.
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Blood-Brain Barrier: From Physiology to Disease and Back
TL;DR: This review examines molecular and cellular mechanisms underlying the establishment of the blood-brain barrier, and examines how BBB dysfunction relates to neurological deficits and other pathologies in the majority of sporadic AD, PD, and ALS cases, multiple sclerosis, other neurodegenerative disorders, and acute CNS disorders.
Journal ArticleDOI
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.
Daniel A. Nation,Melanie D. Sweeney,Axel Montagne,Abhay P. Sagare,Lina M. D'Orazio,Maricarmen Pachicano,Farshid Sepehrband,Amy R. Nelson,David P. Buennagel,Michael G. Harrington,Tammie L.S. Benzinger,Anne M. Fagan,John M. Ringman,Lon S. Schneider,John C. Morris,Helena C. Chui,Meng Law,Arthur W. Toga,Berislav V. Zlokovic +18 more
TL;DR: Neuroimaging and cerebrospinal fluid analyses in humans reveal that loss of blood–brain barrier integrity and brain capillary pericyte damage are early biomarkers of cognitive impairment that occur independently of changes in amyloid-β and tau.
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Pericytes of the neurovascular unit: key functions and signaling pathways
TL;DR: The key signaling pathways between pericytes and their neighboring endothelial cells, astrocytes and neurons that control neurovascular functions are examined and their roles in CNS disorders including rare monogenic diseases and complex neurological disorders are reviewed.