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Berislav V. Zlokovic
Researcher at University of Southern California
Publications - 384
Citations - 54006
Berislav V. Zlokovic is an academic researcher from University of Southern California. The author has contributed to research in topics: Blood–brain barrier & Medicine. The author has an hindex of 105, co-authored 356 publications receiving 44014 citations. Previous affiliations of Berislav V. Zlokovic include Zilkha Neurogenetic Institute & Children's Hospital Los Angeles.
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Journal ArticleDOI
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
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Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.
TL;DR: Mechanisms of BBB dysfunction in neurodegenerative disorders, notably Alzheimer's disease, are examined, and therapeutic opportunities relating to these neurovascular deficits are highlighted.
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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
TL;DR: This Review discusses neuroimaging studies in the living human brain and post-mortem tissue as well as biomarker studies demonstrating BBB breakdown in Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-1-associated dementia and chronic traumatic encephalopathy.
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Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
Axel Montagne,Samuel Barnes,Melanie D. Sweeney,Matthew R. Halliday,Abhay P. Sagare,Zhen Zhen Zhao,Arthur W. Toga,Russell E. Jacobs,Collin Y. Liu,Lilyana Amezcua,Michael G. Harrington,Helena C. Chui,Meng Law,Berislav V. Zlokovic +13 more
TL;DR: The data suggest that BBB breakdown is an early event in the aging human brain that begins in the hippocampus and may contribute to cognitive impairment.
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Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
Masayoshi Shibata,Shinya Yamada,S. Ram Kumar,Miguel Calero,James R. Bading,Blas Frangione,David M. Holtzman,Carol A. Miller,Dudley K. Strickland,Jorge Ghiso,Berislav V. Zlokovic +10 more
TL;DR: It is concluded that the BBB removes Ass from the brain largely via age-dependent, LRP-1-mediated transport that is influenced by alpha(2)M and/or apoE, and may be impaired in AD.