A
Aizhen Guo
Researcher at Huazhong Agricultural University
Publications - 183
Citations - 2218
Aizhen Guo is an academic researcher from Huazhong Agricultural University. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 22, co-authored 152 publications receiving 1609 citations.
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Journal ArticleDOI
Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways.
Jin-lun Lai,Yu-hui Liu,Chang Liu,Mingpu Qi,Rui-ning Liu,Xifang Zhu,Qiu-ge Zhou,Yingyu Chen,Aizhen Guo,Changmin Hu +9 more
TL;DR: Indirubin effectively suppressed LPS-induced inflammation via TLR4 abrogation mediated by the NF-kB and MAPK signaling pathways and may be useful for mastitis prophylaxis.
Journal ArticleDOI
Potential challenges to the Stop TB Plan for humans in China; cattle maintain M. bovis and M. tuberculosis.
Yingyu Chen,Yanjie Chao,Quantao Deng,Tao Liu,Jie Xiang,Jun Chen,Jinhai Zhou,Zhihua Zhan,Youji Kuang,Hong Cai,Huanchun Chen,Aizhen Guo +11 more
TL;DR: In TB high-burden countries like China where bovine and human TB coexists, the fact that cattle maintain both M. bovis and M. tuberculosis would be a potential challenge to both Stop TB Plan of humans andbovine TB eradication scheme.
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Prevalence study and genetic typing of bovine viral diarrhea virus (BVDV) in four bovine species in China.
Mingliang Deng,Sukun Ji,Wentao Fei,Sohail Raza,Chenfei He,Yingyu Chen,Huanchun Chen,Aizhen Guo +7 more
TL;DR: The prevalence of BVDV-1 in bovine species in China and the dominant subtypes revealed and a high proportion of bovines with detectable viral nucleic acids in the sera, even in the presence of high Ab levels, revealed a serious threat to bovin health.
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Comparative geno-plasticity analysis of Mycoplasma bovis HB0801 (Chinese isolate)
Jingjing Qi,Aizhen Guo,Peng Cui,Yingyu Chen,Riaz Mustafa,Xiaoliang Ba,Changmin Hu,Zhidi Bai,Xi Chen,Lei Shi,Huanchun Chen +10 more
TL;DR: Although genomic plasticity was thought to be an evolutionary advantage, it did not apparently affect virulence of M. bovis strains in cattle, and results indicated that both strains were pathogenic to cattle.
Journal ArticleDOI
FimH alleles direct preferential binding of Salmonella to distinct mammalian cells or to avian cells.
Aizhen Guo,Sha Cao,Lingling Tu,Peifu Chen,Chengdong Zhang,Ai-Qing Jia,Weihong Yang,Ziduo Liu,Huanchun Chen,Dieter M. Schifferli +9 more
TL;DR: Allelic variation of the S. enterica FimH adhesin directs not only host-cell-specific recognition, but also distinctive binding to mammalian or avian receptors, and is most relevant that this allele-specific binding profile parallels the host specificity of the respective FIMH-expressing pathogen.