A
Akitoshi Nakashima
Researcher at University of Toyama
Publications - 102
Citations - 4532
Akitoshi Nakashima is an academic researcher from University of Toyama. The author has contributed to research in topics: Pregnancy & Autophagy. The author has an hindex of 28, co-authored 86 publications receiving 3634 citations. Previous affiliations of Akitoshi Nakashima include Brown University.
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Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy
TL;DR: In this article, the authors reviewed the immunological environment in normal pregnancy and complicated pregnancy from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.
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The role of the immune system in preeclampsia.
TL;DR: The cytokine profile in preeclampsia shows that the production of type 1 cytokines, which induce inflammation, is dominant while theProduction of type 2 cytokines is suppressed, and the immunoregulatory system is down-regulated in preeClampsia and persistent inflammation reduces regulatory T cell function.
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Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice
Tomoko Shima,Yasushi Sasaki,Mika Itoh,Akitoshi Nakashima,Naoto Ishii,Kazuo Sugamura,Shigeru Saito +6 more
TL;DR: It is suggested that CD4(+)CD25(+)Foxp3(+) Treg cells are important to mediate maternal tolerance to the allogeneic fetus in the implantation phase and early stage of pregnancy, but T Reg cells might not be necessary for maintenance of the late stage of allogeneIC pregnancy.
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A review of the mechanism for poor placentation in early-onset preeclampsia: the role of autophagy in trophoblast invasion and vascular remodeling.
Shigeru Saito,Akitoshi Nakashima +1 more
TL;DR: The relationship between inadequate autophagy and poor placentation in preeclampsia is discussed and sENG inhibits EVT invasion and vascular remodeling by the inhibition of Autophagy under hypoxic conditions.
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Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer.
Takafumi Nakamura,Tomoko Shima,Ai Saeki,Takao Hidaka,Akitoshi Nakashima,Osamu Takikawa,Shigeru Saito +6 more
TL;DR: IDO expression at the invasive front of cancer cells and APC, and the localization of Foxp3+ Treg cells in front ofcancer tissues, may create a network between IDO and Treg for the induction of immune escape.