Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy
TLDR
In this article, the authors reviewed the immunological environment in normal pregnancy and complicated pregnancy from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.Abstract:
T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-beta and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.read more
Citations
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Inflammation and pregnancy: the role of the immune system at the implantation site.
TL;DR: A new paradigm in terms of the fetal–maternal immune interaction as well as the immunological response of the mother to microorganism is proposed in order to better understand the immunology of pregnancy and to deliver the appropriate treatment to patients with pregnancy complications.
Journal ArticleDOI
Immunology of the Maternal-Fetal Interface
TL;DR: How key immune cell types are either enriched or excluded from the decidua, how their function is regulated within the decodua, and how they variously contribute to pregnancy success or failure are discussed.
Journal ArticleDOI
The unique immunological and microbial aspects of pregnancy
TL;DR: Recent evidence that supports the idea that immunological responses at the receptive maternal–fetal interface are not simply suppressed but are instead highly dynamic is discussed.
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Monocytes and Macrophages in Pregnancy and Pre-Eclampsia
TL;DR: The role of monocytes and macrophages in the pathophysiology of pre-eclampsia is focused on and appears to be present in larger numbers and are also activated.
Journal ArticleDOI
Physiological and molecular determinants of embryo implantation
Shuang Zhang,Hai-Yan Lin,Shuangbo Kong,Shumin Wang,Hongmei Wang,Haibin Wang,D. Randall Armant,D. Randall Armant +7 more
TL;DR: A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women.
References
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