A
Alex Kartheuser
Researcher at Cliniques Universitaires Saint-Luc
Publications - 139
Citations - 4606
Alex Kartheuser is an academic researcher from Cliniques Universitaires Saint-Luc. The author has contributed to research in topics: Familial adenomatous polyposis & Colorectal cancer. The author has an hindex of 30, co-authored 126 publications receiving 3719 citations. Previous affiliations of Alex Kartheuser include Catholic University of Leuven & Université catholique de Louvain.
Papers
More filters
Journal ArticleDOI
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
Franck Pagès,Bernhard Mlecnik,Florence Marliot,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Fang Shu Ou,Carlo Bifulco,Alessandro Lugli,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Y. Wang,Julia Y. Wang,Prashant Bavi,Michael H.A. Roehrl,Michael H.A. Roehrl,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,Seong Jun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Bénédicte Buttard,Bénédicte Buttard,Bénédicte Buttard,Mihaela Angelova,Mihaela Angelova,Mihaela Angelova,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Pauline Maby,Pauline Maby,Pauline Maby,Sarah E. Church,Helen K. Angell,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Daniela Bruni,Daniela Bruni,Daniela Bruni,Carine El Sissy,Nacilla Haicheur,Amos Kirilovsky,Anne Berger,Christine Lagorce,Jeffrey P. Meyers,Christopher Paustian,Zipei Feng,Carmen Ballesteros-Merino,Jeroen R. Dijkstra,Carlijn van de Water,Shannon van Vliet,Nikki Knijn,Ana Maria Mușină,Dragos Viorel Scripcariu,Boryana Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,Kyogo Itoh,P. Patel,Hemangini H. Vora,Birva Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Yutaka Kawakami,Francesco M. Marincola,Paolo A. Ascierto,Daniel J. Sargent,Bernard A. Fox,Bernard A. Fox,Jérôme Galon,Jérôme Galon,Jérôme Galon +120 more
TL;DR: The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer.
Journal ArticleDOI
Evolution of Metastases in Space and Time under Immune Selection.
Mihaela Angelova,Bernhard Mlecnik,Angela Vasaturo,Gabriela Bindea,Tessa Fredriksen,Lucie Lafontaine,Bénédicte Buttard,Erwan Morgand,Daniela Bruni,Anne Jouret-Mourin,Catherine Hubert,Alex Kartheuser,Yves Humblet,Michele Ceccarelli,Najeeb Syed,Francesco M. Marincola,Davide Bedognetti,Marc Van den Eynde,Marc Van den Eynde,Jérôme Galon +19 more
TL;DR: A parallel selection model of metastatic progression, where branched evolution could be traced back to immune-escaping clones is proposed, which could inform the understanding of cancer dissemination and the development of immunotherapeutics.
Journal ArticleDOI
The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients.
Marc Van den Eynde,Bernhard Mlecnik,Gabriela Bindea,Tessa Fredriksen,Sarah E. Church,Lucie Lafontaine,Nacilla Haicheur,Florence Marliot,Mihaela Angelova,Angela Vasaturo,Daniela Bruni,Anne Jouret-Mourin,Pamela Baldin,Nicolas Huyghe,Karin Haustermans,Annelies Debucquoy,Eric Van Cutsem,Jean-François Gigot,Catherine Hubert,Alex Kartheuser,Christophe Remue,Daniel Léonard,Viia Valge-Archer,Franck Pagès,Jean-Pascal Machiels,Jérôme Galon +25 more
TL;DR: The immune phenotype of the least-infiltrated metastasis had a stronger association with patient outcome than other metastases and the predictive accuracy of the Immunoscore from a single biopsy was superior to the one of programmed cell death ligand 1 (PD-L1).
Journal ArticleDOI
Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer.
J-P. Machiels,Christine Sempoux,Pierre Scalliet,J-C. Coche,Yves Humblet,E. Van Cutsem,Joseph Kerger,J-L Canon,Marc Peeters,Selda Aydin,Stéphanie Laurent,Alex Kartheuser,Blanche M. De Coster,Sarah Roels,J.F. Daisne,B. Honhon,Lionel Duck,C. Kirkove,Ma Bonny,Karin Haustermans +19 more
TL;DR: Preoperative radiotherapy in combination with capecitabine and cetuximab is feasible with some patients achieving pathological downstaging, and no dose-limiting toxicity occurred.
Journal ArticleDOI
Ileal pouch-anal anastomosis as the first choice operation in patients with familial adenomatous polyposis: a ten-year experience
Alex Kartheuser,Rolland Parc,Christophe Penna,Emmanuel Tiret,Pascal Frileux,Laurent Hannoun,Bernard Nordlinger,Jean Joygue +7 more
TL;DR: Morbidity and functional results after IPAA for familial adenomatous polyposis do not differ from those reported after IRA and because of the risk of rectal cancer after ileorectal anastomosis, IPAA with endoanal mucosectomy is their first choice.